摘要
目的分析自身抗体检测对自身免疫性肝炎的临床诊断价值。方法选取2019年11月至2020年10月于本院体检的65例健康体检者作为健康组,选取同期本院收治的65例慢性病毒性肝炎患者作为对照组,选取同期本院收治的65例自身免疫性肝炎患者作为观察组。三组研究对象均接受常规生化指标检查、自身抗体检测。比较三组的各项常规生化指标、自身抗体阳性检出率、ANA滴度分布情况及阳性率、各个ANA核型检出率。结果对照组和观察组的各项常规生化指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)、直接胆红素(DBIL)、总胆红素(TBIL)、白球比]水平比较,差异无统计学意义(P>0.05);对照组和观察组的ALT、AST、ALP、GGT、DBIL、TBIL水平均高于健康组,白球比低于健康组,差异具有统计学意义(P<0.05)。观察组的7项自身抗体[抗肝肾微粒体抗体(LKM)、抗肝细胞浆抗体1型(LC-1)、抗可溶性肝抗原抗体(SLA)、抗核抗体(ANA)、抗线粒体抗体(AMA)、抗平滑肌抗体(SMA)、核周型抗中性粒细胞胞浆抗体(PANCA)]阳性检出率、联合检测阳性检出率均高于健康组和对照组,差异具有统计学意义(P<0.05)。观察组的ANA滴度阳性检出率高于健康组和对照组,差异具有统计学意义(P<0.05)。观察组的核颗粒型检出率低于对照组,核均质型检出率高于对照组,差异具有统计学意义(P<0.05)。结论自身抗体联合检测能够准确鉴别诊断自身免疫性肝炎,为临床诊治提供可靠的数据支持。
Objective To study the clinical diagnostic value of autoantibody detection in autoimmune hepatitis.Methods A total of 65 healthy individuals who underwent physical examination in our hospital from November 2019 to October 2020 were selected as health group,65 patients with chronic viral hepatitis admitted in our hospital during the same period were selected as control group,and 65 patients with autoimmune hepatitis admitted in our hospital during the same period were selected as observation group.The research objects in the three groups all received routine biochemical indexe examination and autoantibody detection.The routine biochemical indexes,the positive detection rate of autoantibody,the ANA titer distribution and positive rate,and the detection rate of each ANA karyotype were compared among the three groups.Results There were no significant differences in the levels of routine biochemical indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),γ-glutamyl transpeptidase(GGT),direct bilirubin(DBIL),total bilirubin(TBIL),globulin ratio]between the control group and the observation group(P>0.05);the levels of ALT,AST,ALP,GGT,DBIL and TBIL in the control group and the observation group were higher than those in the healthy group,globulin ratio was lower than that in the healthy group,and the differences were statistically significant(P<0.05).The positive detection rates of 7 autoantibodies[anti liver and kidney microsomal antibody(LKM),anti hepatocyte plasma antibody(LC-1),anti soluble liver antigen antibody(SLA),antinuclear antibody(ANA),anti mitochondrial antibody(AMA),anti smooth muscle antibody(SMA)and perinuclear antineutrophil cytoplasmic antibody(PANCA)]and the positive detection rate of combined detection in the observation group were higher than those in the healthy group and the control group,and the differences were statistically significant(P<0.05).The positive rate of ANA titer in the observation group was higher than that in the healthy group and the control group,and the differences were statistically significant(P<0.05).The detection rate of nuclear granular type in the observation group was lower than that in the control group,the detection rate of nuclear homogeneous type was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion The combined detection of autoantibodies can accurately differentiate autoimmune hepatitis,and provide reliable data support for clinical diagnosis and treatment.
作者
王玲
朱文静
WANG Ling;ZHU Wenjing(Tangcheng Hospital of Xi'an,Xi'an 710016;Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710001,China)
出处
《临床医学研究与实践》
2022年第9期123-126,共4页
Clinical Research and Practice
