摘要
慢性间歇低氧(chronic intermittent hypoxia,CIH)是阻塞性睡眠呼吸暂停(obstructive sleep ap-nea,OSA)的重要病理生理学特征,参与OSA相关并发症的发生发展[1]。认知障碍是OSA常见的并发症之一,其患病率高达30%以上[2],严重影响患者的生活质量。因此,探讨CIH导致认知障碍的具体机制,为临床提供新的治疗思路十分重要。小胶质细胞作为中枢神经系统的免疫细胞,在维持中枢神经系统稳态中起重要作用。
Chronic intermittent hypoxia(CIH)is an important pathophysiological feature of obstructive sleep apnea,which is involved in the occurrence and development of cognitive impairment.As the immune cells in the central nervous system,microglia plays an important role in the pathological processes of neurodegenerative diseases.This article reviews the effect of CIH on microglia including its activation,phenotypic transformation,proliferation,and apoptosis.The role of microglia in CIH-related cognitive impairment includes the decrease in protective effect and the increase in harmful effect caused by the neuroinflammation and synaptic phagocytosis of microglia.
作者
徐家欢
王玮
XU Jia-huan;WANG Wei(Department of Respiratory and Critical Care Medicine,The First Hospital of China Medical University,Shenyang 110001,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2022年第3期566-571,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81670085)。
关键词
慢性间歇低氧
认知障碍
小胶质细胞
Chronic intermittent hypoxia
Cognitive impairment
Microglia
