摘要
由于肿瘤细胞快速增殖生长,许多实体瘤中存在缺氧的微环境,缺氧诱导因子对于感知肿瘤内的氧张力并随后介导缺氧反应激活至关重要。肝细胞癌(HCC)是最缺氧的肿瘤之一,本文总结了缺氧诱导因子通过促进糖酵解、血管生成、侵袭转移、免疫逃避、癌症干细胞化等方式促进HCC发生发展的作用机制。当前,缺氧诱导因子抑制剂靶向药物的研发在HCC治疗领域具有广阔前景,缺氧诱导因子检测对HCC预后评估也具有潜在价值。
Due to the rapid proliferation and growth of tumor cells,hypoxic microenvironment exists in many solid tumors,and hypoxia inducible factors(HIF)are critical for sensing oxygen tension within tumors and subsequently mediating the activation of hypoxia responses.Hepatocellular carcinoma(HCC)is one of the most hypoxic tumors.This article summarizes the mechanism of action of HIF in promoting the development and progression of HCC by promoting glycolysis,angiogenesis,invasion and metastasis,immune escape,and cancer stem cell formation.At present,the development of targeted drugs for HIF inhibitors has broad prospects in the treatment of HCC,and the detection of HIF also has a potential value in prognostic evaluation HCC.
作者
李宏一
罗业浩
罗筱凡
吴笛
秦黄冠
蓝绍航
吕挺
庞宇舟
LI Hongyi;LUO Yehao;LUO Xiaofan;WU Di;QIN Huangguan;LAN Saohang;LYU Ting;PANG Yuzhou(Key Laboratory of Applied Basic Research of Guangxi Zhuang Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China;Department of Medicine,Hubei Minzu University,Enshi,Hubei 445000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第3期688-692,共5页
Journal of Clinical Hepatology
基金
广西医学高层次骨干人才培养‘139’计划资助项目(桂卫科教发〔2020〕15号)
广西壮族自治区卫生健康委员会壮医应用基础研究重点实验室项目(桂卫科教发〔2020〕17号)
广西中医药大学“岐黄工程”高层次人才团队培育项目(2021003)
中医学广西一流学科(桂教科研〔2018〕12号)。
关键词
癌
肝细胞
缺氧诱导因子
分子靶向治疗
预后
Carcinoma,Hepatocellular
Hypoxia-Inducible Factor
Molecular Targeted Therapy
Prognosis
