摘要
目的探讨单硝酸异山梨酯联合丹参多酚酸盐对冠心病心绞痛患者的疗效。方法选取周口永善医院2019年2月至2021年2月收治的98例冠心病心绞痛患者为研究对象,依据随机数表法分为试验组和对照组,各49例。对照组接受单硝酸异山梨酯治疗,试验组在对照组基础上增加丹参多酚酸盐治疗。比较两组心电图、血脂及心功能指标。结果治疗前,两组各指标相比,差异无统计学意义(P>0.05)。治疗后,试验组缺血发作次数少于对照组,ST段下降幅度小于对照组,ST段下降时间短于对照组(P<0.05)。试验组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平较对照组低,高密度脂蛋白胆固醇(HDL-C)水平较对照组高(P<0.05)。试验组左室射血分数(LVEF)较对照组高,左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)较对照组小(P<0.05)。结论单硝酸异山梨酯与丹参多酚酸盐联合治疗冠心病心绞痛患者,可有效调节血脂水平,缓解患者心肌缺血情况,改善心功能。
Objective To investigate the efcacy of isosorbide mononitrate combined with salvianolate in patients with coronary heart disease and angina pectoris.Methods A total of 98 patients with coronary heart disease and angina pectoris who were admitted to Zhoukou Yongshan Hospital from February 2019 to February 2021 were selected as the research objects,and were divided into the experimental group and the control group according to the random mumber table method,with 49 cases in each group.The control group recei ved isosorbide mononitrate treatment,and the experimental group received salvianolate treatment on the basis of the control group.The electrocardiogram,blood lipids and cardiac function indexes were compared between the two groups.Results Before treatment,there was no statistical difference in each index between the two groups(P>0.05).Afer treatment,the number of ischemic attacks in the experimental group was less than that in the control group,the ST segment decline was less than that in the control group,and the ST segment decline time was shorter than that in the control group(P<0.05).The levels of total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in the experimental group were lower than those in the control group,and the level of high-density lipoprotein cholesterol(HDL-C)was higher than that in the control group(P<0.05).The left ventricular ejection fraction(LVEF)in the experimental group was higher than that in the control group,and the left ventricular end-systolic volume(LVESV)and left ventricular end-diastolie volume(LVEDV)were smaller than those in the control group(P<0.05).Conclusion Isosorbide mononitrate combined with salvianolate in the treatment of patients with coronary heart disease and angina pectoris can efectively regulate blood lipid levels,relieve myocardial ischemia and improve cardiac function.
作者
贾其威
齐倩楠
刘洁
JIA Qiwei;QI Qiannan;LIU Jie(Department of Cardiology,Zhoukou Yongshan Hospital,Zhoukou 461300,China)
出处
《河南医学研究》
CAS
2022年第3期527-530,共4页
Henan Medical Research
关键词
冠心病
心绞痛
单硝酸异山梨酯
丹参多酚酸盐
血脂
心功能
coronary heart disease
angina pectoris
isosorbide mononitrate
salvi anolate
blood lipid
cardiac function
