摘要
目的分析西格列汀治疗老年糖尿病的临床疗效。方法选取该院2018年3月—2020年9月内分泌科收治的110例老年2型糖尿病患者作为研究对象,根据患者的治疗意愿以及药物的不同分为对照组以及研究组,各55例。对照组患者采用瑞格列奈治疗,研究组患者接受西格列汀治疗。比较两组患者治疗前与治疗3个月后的空腹血糖、餐后2 h血糖以及糖化血红蛋白水平,血管功能、不良反应发生率。结果两组患者在治疗3个月后空腹血糖、餐后2 h血糖以及糖化血红蛋白水平与治疗前相比明显下降,研究组患者3个月后空腹血糖(6.42±0.41)mmol/L、餐后2 h血糖(9.13±1.06)mmol/L以及糖化血红蛋白水平(6.61±0.37)%明显低于对照组,差异有统计学意义(t=10.974、7.814、13.911,P<0.05)。治疗后,对照组患者的血管内皮依赖性舒张功能与颈动脉内膜中层厚度和治疗前比较,差异无统计学意义(P>0.05)。而研究组患者治疗3个月后和治疗前以及对照组比较,血管内皮依赖性舒张功能指标上升,颈动脉内膜中层厚度下降,差异有统计学意义(P<0.05)。治疗期间研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论采用西格列汀治疗老年糖尿病患者能够有效降低患者血糖水平,对老年患者心脑血管具有一定的保护效果,安全性更高,值得应用。
Objective To analyze the clinical efficacy of sitagliptin in the treatment of senile diabetes.Methods 110 elderly patients with type 2 diabetes who were admitted to the Department of Endocrinology in the hospital from March 2018 to September 2020 were selected as the research objects.The patients were divided into a control group and a study group according to their willingness to treat and different drugs,with 55 cases in each group.Patients in the control group were treated with repaglinide,and patients in the study group were treated with sitagliptin.The fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels,vascular function,and incidence of adverse reactions were compared between the two groups of patients before and after 3 months of treatment.Results The fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels of the two groups of patients decreased significantly after 3 months of treatment compared with those before treatment.The fasting blood glucose(6.42±0.41)mmol/L,2 h postprandial blood glucose(9.13±1.06)mmol/L,and glycosylated hemoglobin levels(6.61±0.37)%of patients in the study group were significantly lower than those in the control group after 3 months,the difference was statistically significant(t=10.974,7.814,13.911,P<0.05).After treatment,the endothelium-dependent vasodilation function and carotid artery intima-media thickness of the control group was compared with that before treatment,the difference was statistically significant(P<0.05).After 3 months of treatment,compared with before treatment and the control group,the indexes of vascular endothelium-dependent relaxation function increased and the carotid intima-media thickness decreased,and the difference was statistically significant(P<0.05).During the treatment period,the incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of sitagliptin in the treatment of elderly diabetic patients can effectively reduce the blood glucose level of the patients.The cardiovascular and cerebrovascular in elderly patients has a certain protective effect and is more safe.It is worth applying.
作者
赵秀伟
ZHAO Xiuwei(Department of Endocrinology,People's Hospital of Jiaxiang County,Jining,Shandong Province,272400 China)
出处
《糖尿病新世界》
2021年第24期73-75,共3页
Diabetes New World Magazine
关键词
糖尿病
西格列汀
瑞格列奈
血糖
血管内皮
疗效
Diabetes
Sitagliptin
Repaglinide
Blood glucose
Vascular endothelium
Curative effect
