摘要
目的:分析用利福布汀联合洛匹那韦利托那韦治疗艾滋病合并肺结核的效果及安全性。方法:选取东莞市第九人民医院2019年9月至2020年9月收治的艾滋病合并肺结核患者30例为研究对象。按随机双盲法将其分为对照组和观察组(15例/组)。为对照组患者采用利福布汀进行治疗,为观察组患者采用利福布汀联合洛匹那韦利托那韦进行治疗,然后对比两组患者的疗效。结果:观察组患者治疗的总有效率高于对照组患者,P<0.05。治疗后,观察组患者血清免疫球蛋白G、免疫球蛋白A、免疫球蛋白M的水平均高于对照组患者,P<0.05;两组患者不良反应的发生率相比,P>0.05。结论:用利福布汀联合洛匹那韦利托那韦治疗艾滋病合并肺结核的效果确切,且安全性较高。
Objective:To analyze the efficacy and safety of rifambutin combined with lopinavir ritonavir in the treatment of AIDS complicated with tuberculosis.Methods:Thirty AIDS patients with tuberculosis admitted to The Ninth People’s Hospital of Dongguan city from September 2019 to September 2020 were selected as the research objects.They were randomly divided into control group and observation group(15 cases/group)by double-blind method.Patients in the control group were treated with rifambutin,and patients in the observation group were treated with rifambutin combined with lopinavir or ritonavir,and then the efficacy of the two groups was compared.Results:The total effective rate of observation group was higher than control group,P<0.05.After treatment,the levels of serum immunoglobulin G,immunoglobulin A and immunoglobulin M in observation group were higher than those in control group,P<0.05;The incidence of adverse reactions in 2 groups was compared,P>0.05.Conclusion:Rifambutin combined with lopinavir ritonavir is effective and safe in the treatment of AIDS complicated with tuberculosis.
作者
王燕浩
WANG Yanhao(Department of Infectious Diseases,The Ninth People’s Hospital of Dongguan,Dongguan 523000)
