摘要
目的探讨宜肺益气法治疗肺气虚型变应性鼻炎的临床疗效及对Th1细胞/Th2细胞(Th1/Th2)和免疫球蛋白E/免疫球蛋白G4(IgE/IgG4)的影响。方法将102例肺气虚型变应性鼻炎患者随机分为研究组与对照组,各51例,对照组给予氯雷他定治疗,研究组在对照组治疗的基础上联合温肺止流丹治疗,观察比较2组治疗后的临床疗效,比较2组治疗前后喷嚏、鼻塞和鼻痒的症状评分以及血清Th1/Th2细胞因子、IgE和IgG4水平。结果治疗后,研究组治疗总有效率(36%vs 24%)以及血清干扰素γ(IFN-γ)[(65.84±7.67)pg·mL^(-1)vs(51.65±6.22)pg·mL^(-1)]、白细胞介素-2(IL-2)[(8.15±1.00)pg·mL^(-1)vs(6.13±1.13)pg·mL^(-1)]水平明显高于对照组,差异均有统计学意义(P<0.05),喷嚏[(0.50±0.05)分vs(0.92±0.09)分]、鼻塞[(0.77±0.07)分vs(1.31±0.14)分]和鼻痒[(0.62±0.06)分vs(1.13±0.14)分]的症状评分明显低于对照组,血清白细胞介素-4(IL-4)[(46.62±5.71)pg·mL^(-1)vs(51.01±6.10)pg·mL^(-1)]、白细胞介素-13(IL-13)[(23.61±3.46)pg·mL^(-1)vs(34.12±4.51)pg·mL^(-1)]、IgE[(111.12±24.21)u·mL^(-1)vs(175.06±30.63)u·mL^(-1)]和IgG4[(28.22±11.96)u·mL^(-1)vs(56.77±15.26)u·mL^(-1)]水平明显低于对照组,差异有统计学意义(P<0.05)。结论宜肺益气法能提高肺气虚型变应性鼻炎患者的临床疗效,改善临床症状,调节Th1/Th2细胞因子失衡,减轻免疫炎症反应。
Objective To explore the clinical curative effect of Yifei Yiqi method on allergic rhinitis of lung-qi deficiency and its influences on Th1 cell/Th2 cells(Th1/Th2)and immunoglobulin E/recombinant immunoglobulin G4(IgE/IgG4).Methods 102 patients with allergic rhinitis of lung-qi deficiency were randomly divided into study group and control group,51 cases in each group.The control group were treated with loratadine,while the study group were additionally treated with Wenfei Zhiliu Dan medicine.Clinical curative effect after treatment was observed and compared between the 2 groups.The scores of sneezing,nasal congestion and rhinocnesmus,the levels of serum Th1/Th2 cytokine,IgE and IgG4 before and after treatment were compared between the 2 groups.Results After treatment,the total response rate of treatment,the levels of serum interferonγ(IFN-γ)and interleukin-2(IL-2)in study group were significantly higher than those in control group[36%vs 24%,(65.84±7.67)pg·mL^(-1) vs(51.65±6.22)pg·mL^(-1),(8.15±1.00)pg·mL^(-1) vs(6.13±1.13)pg·mL^(-1)],the differences were statistically significant(P<0.05),while the scores of sneezing,nasal congestion and rhinocnesmus,the levels of serum interleukin-4(IL-4),interleukin-13(IL-13),IgE and IgG4 were significantly lower than those in control group[(0.50±0.05)points vs(0.92±0.09)points,(0.77±0.07)points vs(1.31±0.14)points,(0.62±0.06)points vs(1.13±0.14)points,(46.62±5.71)pg·mL^(-1) vs(51.01±6.10)pg·mL^(-1),(23.61±3.46)pg·mL^(-1) vs(34.12±4.51)pg·mL^(-1),(111.12±24.21)u·mL^(-1) vs(175.06±30.63)u·mL^(-1),(28.22±11.96)u·mL^(-1) vs(56.77±15.26)u·mL^(-1)],the differences were statistically significant(P<0.05).Conclusion Yifei Yiqi method can improve the clinical curative effect in patients with allergic rhinitis of lung-qi deficiency,improve clinical symptoms,regulate imbalance of Th1/Th2 cytokine,and reduce immune inflammation reactions.
作者
柳普照
康浩然
张治成
杨晓刚
LIU Puzhao;KANG Haoran;ZHANG Zhicheng;YANG Xiaogang(Department of Otolaryngology,the First Affiliated Hospital of He′nan University of Traditional Chinese Medicine,Zhengzhou 450002,China)
出处
《西北药学杂志》
CAS
2021年第6期1001-1004,共4页
Northwest Pharmaceutical Journal
基金
河南省中医药科学研究专项课题(编号:2019ZY2115)。
