摘要
目的:研究McGill大学开发的蒙特卡罗治疗计划系统MMCTP(McGill Monte Carlo treatment planning system)用于临床剂量学研究的可行性。方法:选取某院2012年6月至2016年12月采用RapidArc加速器治疗的40例患者,按照治疗部位分为头部组、胸部组、腹部组和盆腔组,每组10例患者。通过Eclipse计划系统导出40例患者的治疗计划信息,并导入MMCTP,通过MMCTP调用EGSnrc程序进行蒙特卡罗模拟,并计算得到新的剂量学结果。比较2种治疗计划系统的靶区和危及器官的物理剂量学参数及Gamma通过率。采用IBM SPSS 26.0软件进行统计学分析。结果:2种治疗计划系统的靶区剂量学参数中,除胸部组的D_(98)、D_(mean)和HI差异有统计学意义外(t分别为-3.947、-4.385和3.959,P<0.05),其余3组病例的靶区剂量学参数差异均无统计学意义(P>0.05)。2种治疗计划系统的危及器官剂量学参数和Gamma通过率差异均无统计学意义(P>0.05)。结论:MMCTP的剂量计算结果准确、可靠,可用于放疗剂量学的研究。
Objective To discuss the feasibility of McGill Monte Carlo treatment planning system(MMCTP)by McGill Uni-versity applied for clinical dosimetry research.Methods Forty patients undergoing RapidArc treatment at some hospital from June 2012 to December 2016 were selected and divided into a head group,a chest group,an abdomen group and a pelvis group according to the treatment site,with 10 patients in each group.The treatment planning information of the 40 patients was exported through the Eclipse planning system and imported into MMCTP,where the EGSnrc program was called through MMCTP to perform Monte Carlo simulation and calculate the new dosimetry results.Physical dosimetry parameters and Gamma pass rates for the target areas and organs at risk were compared between the 2 treatment planning systems.Statistical analysis was carried out using IBM SPSS 26.0 software.Results The two treatment planning systems had all the dosimetry parameters at the target areas not statistically different(P>0.05)except the D_(98),D_(mean) and HI at the chest group(with t values being-3.947,-4.385 and 3.959 respectively,P<0.05).There were no statistically significant differences between the dosimetry parameters and Gamma pass rates for the organs at risk by the two treatment planning systems(P>0.05).Conclusion MMCTP has high accuracy and reliability when used for dose calculation,and thus can be used for radiotherapy dosimetry studies.
作者
孟慧鹏
孙小喆
付娟
段敬豪
王克强
赵前锋
明鑫
MENG Hui-peng;SUN Xiao-zhe;FU Juan;DUAN Jing-hao;WANG Ke-qiang;ZHAO Qian-feng;MING Xin(Characteristic Medical Center of PAP,Tianjin 300162,China;School of Precision Instrument and Opto-electronics Engineering,Tianjin University,Tianjin 300072,China;Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang 441021,Hubei Province,China;School of Biomedical Engineering,Tianjin Medical University,Tianjin 300050,China)
出处
《医疗卫生装备》
CAS
2022年第1期45-49,共5页
Chinese Medical Equipment Journal
基金
国家自然科学基金项目(11805144)。
