摘要
目的:探讨活络止痛生肌方熏洗联合踏车运动疗法对糖尿病足溃疡患者创面愈合的影响。方法:选取2020年1-12月在佛山市第五人民医院确诊的70例糖尿病足溃疡患者,采用简单随机分组法将患者分为观察组和对照组,每组35例。在基础治疗的基础上,对照组接受踏车运动疗法治疗,观察组采用活络止痛生肌方熏洗治疗联合踏车运动疗法,均持续治疗1个月。比较两组临床疗效,分别于治疗前后,观察两组的足溃疡创面愈合情况,以及肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)、终末糖基化产物(AGEs)、血管内皮生长因子(VEGF)、碱性成纤维生长因子(bFGF)和表皮生长因子(EGF)的变化。结果:观察组总有效率为94.29%,与对照组的82.86%相比,差异无统计学意义(P>0.05);治疗后,观察组的创面面积和创面深度显著小于对照组,创面氧分压显著高于对照组(P<0.05);观察组的IL-6、TNF-α和AGEs水平均显著低于对照组(P<0.05);观察组的bFGF、VEGF和EGF水平均显著高于对照组(P<0.05)。结论:活络止痛生肌方熏洗联合踏车运动疗法治疗糖尿病足溃疡患者的效果较好,可以促进创面的愈合,提高生长因子水平,降低炎症反应。
Objective:To explore the effect of Huoluo Zhitong Shengji Formula fumigation and washing combined with treadmill exercise therapy on wound healing in patients with diabetic foot ulcers.Method:A total of 70 patients with diabetic foot ulcers diagnosed in Foshan Fifth People’s Hospital from January to December 2020 were randomly divided into observation group and control group,35 cases in each group.In the basic treatment,the control group was treated with treadmill exercise,and the observation group was treated with Huoluo Zhitong Shengji Formula fumigation and washing combined with treadmill exercise,both of which lasted for 1 month.The clinical efficacy of the two groups was compared,and the foot ulcer wound healing and the changes of tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),advanced glycation end products (AGEs),vascular endothelial growth factor (VEGF),basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) were observed before and after treatment.Result:The total effective rate of the observation group was 94.29%,which was not significantly significant compared with 82.86% in the control group (P>0.05).After treatment,the wound area and depth of the observation group were significantly smaller than those of the control group,and the oxygen partial pressure of the wound was significantly higher than that of the control group (P<0.05).The levels of IL-6,TNF-α and AGEs in the observation group were significantly lower than those in the control group (P<0.05),the levels of bFGF,VEGF and EGF in the observation group were significantly higher than those in the control group (P<0.05).Conclusion:Huoluo Zhitong Shengji Formula fumigation and washing combined with treadmill exercise therapy is effective in treating diabetic foot ulcers,which can promote wound healing,increase the level of growth factor,and reduce inflammation.
作者
苏影红
李结霞
何伟玲
SU Yinghong;LI Jiexia;HE Weiling(Foshan Fifth People’s Hospital,Foshan 528211,China)
出处
《中外医学研究》
2022年第2期154-157,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
活络止痛生肌方
踏车运动疗法
糖尿病足溃疡
创面愈合
Huoluo Zhitong Shengji Formula
Treadmill exercise therapy
Diabetic foot ulcers
Wound healing
