摘要
脓毒症相关毛细血管渗漏综合征(sepsis associated capillary leak syndrome,SACLS)是一种以广泛且可逆的毛细血管渗漏为病理基础,以低血压、血液浓缩和低白蛋白血症为临床特征的脓毒症相关继发疾病。SACLS在一定程度上可加速脓毒症患者病情恶化,因此干预治疗SACLS对脓毒症患者的救治具有重要意义。本文对SACLS的临床表现、病理机制进行总结,分析各类血管活性因子在血管渗漏中发挥的作用,讨论SACLS患者的液体复苏治疗进展,以期为临床优化SACLS的诊疗手段提供帮助。
Sepsis associated capillary leak syndrome(SACLS)is a sepsis-related secondary disease based on extensive and reversible capillary leak and characterized clinically by hypotension,hemoconcentration and hypoalbuminemia.Since SACLS accelerates the deterioration of sepsis patients to a certain extent,the intervention treatment for SACLS is of great significance.This review describes the clinical manifestations and pathological mechanisms of SACLS,with an emphasis on the roles of various vasoactive factors in vascular leakage and the fluids to be used for resuscitation in patients with SACLS.It is expected to provide help for clinical optimization of the diagnosis and treatment of SACLS.
作者
潘郭海容
田圆
王瀚黎
梁群
Pan Guo-hai-rong;Tian Yuan;Wang Han-li;Liang Qun(Clinical college,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
出处
《中国急救医学》
CAS
CSCD
2022年第2期163-169,共7页
Chinese Journal of Critical Care Medicine
基金
国家自然科学基金面上项目(81974557)
国家自然科学基金面上项目(81774276)
国家中医管理局新冠肺炎中医药应急专项课题(2020ZYLCYJ 06-2)
哈尔滨市科技创新人才研究专项资金(2017RAXXJ037)
黑龙江中医药大学校级科技创新研究平台项目(2018pt06)。
