摘要
Exosomes play a role as mediators of cell-to-cell communication,thus exhibiting pleiotropic activities to homeostasis regulation.Exosomal non-coding RNAs(ncRNAs),mainly microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),are closely related to a variety of biological and functional aspects of human health.When the exosomal ncRNAs undergo tissuespecific changes due to diverse internal or external disorders,they can cause tissue dysfunction,aging,and diseases.In this review,we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases.In addition,we explore the current knowledge on the roles of exosomal miRNAs,lncRNAs,and circRNAs in human health and diseases,including cancers,metabolic diseases,neurodegenerative diseases,cardiovascular diseases,autoimmune diseases,and infectious diseases,to determine their potential implication in biomarker identification and therapeutic exploration.
基金
This work was supported by the National Natural Science Foundation of China(No.82071593,81770833,81974223,and 82101663)
the Fundamental Research Funds For the Central Universities of Central South University(NO.2019zzts354).
