摘要
糖尿病患者由于血糖升高等代谢紊乱,导致机体免疫功能受损、肺组织结构损伤和功能下降,有利于呼吸道病原菌的生长,易发生肺部感染。体外及体内研究证实在高葡萄糖及代谢紊乱环境下,病原菌在呼吸道定植增多、生长代谢加快,易于细菌生物被膜形成,容易诱发感染且增加对抗菌药物的抵抗力。革兰阴性杆菌和金黄色葡萄球菌是糖尿病患者肺部感染的常见致病菌,机会感染也更容易在糖尿病患者中发生。因此,对于糖尿病患者,控制血糖有利于降低感染的发生,对合并肺部感染的患者需要有针对性地选择适当抗菌药物,以改善患者预后。
Due to metabolic disorders such as hyperglycemia,diabetic patients suffer impairment of immune function,damage of lung tissue structure and decline of pulmonary function,which is conducive to the growth of pathogens in the respiratory tract and makes the patient susceptible to pulmonary infection.In vitro and in vivo studies have confirmed that in the environment of high glucose and metabolic disorders,pathogens increase colonization in the respiratory tract,accelerate their growth and metabolism,and are prone to form bacterial biofilm,which can easily induce infection and increase resistance to antibiotics.Gram-negative bacilli and Staphylococcus aureus are common pathogens of pulmonary infections in diabetic patients.Opportunistic infections are also more likely to occur in diabetic patients.Therefore,the control of blood glucose in diabetic patients can help reduce the occurrence of infection,and patients with pulmonary infection need to be treated with appropriate antibiotics to improve the prognosis of patients.
作者
程思珺
陈愉
Cheng Sijun;Chen Yu(Department of Health Management,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Pulmonary and Critical Care Medicine,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《国际呼吸杂志》
2021年第24期1881-1885,共5页
International Journal of Respiration
基金
国家重点研发计划(2017YFC1309702)。
关键词
感染
肺部
糖尿病
代谢紊乱
病原微生物
Infection,pulmonary
Diabetes mellitus
Metabolic disorders
Pathogens
