摘要
目的:比较布托啡诺与地佐辛应用于全麻下乳腺良性肿瘤切除术中的辅助效果。方法:选取2019年1月至2019年12月在佛山市第一人民医院接受全麻下乳腺良性肿物切除术的患者90例,随机分为A组、B组与C组,每组30例患者。在单纯丙泊酚静脉全麻基础上,A组缓慢静脉注射布托啡诺10 μg·kg^(-1),B组缓慢静脉注射地佐辛0.1 mg·kg^(-1),C组静脉注射同等容量0.9 %氯化钠注射液。观察三组患者术中各个时间点的平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(SpO_(2)),以及术后清醒时间、术后镇痛评分、术中丙泊酚总用药量和不良反应等情况。结果:给药前(T1)~缝合时(T3),C组患者的HR明显高于A组和B组,差异具有统计学意义(P<0.05)。A、B组患者术后清醒时间均短于C组,术后30 min疼痛数字评分法(NRS)评分均低于C组,丙泊酚总用药量均少于C组,差异均具有统计学意义(P<0.05)。结论:应用布托啡诺后或地佐辛辅助丙泊酚非插管静脉全麻下行单个乳腺良性肿瘤切除术,能降低患者术中不良反应的发生率,术后清醒时间较单纯丙泊酚静脉全麻组短,两者之间的不良反应均无引起严重后果,人为干预均可缓解;且应用布托啡诺或地佐辛后,能明显减少患者的术后疼痛感,达到快速康复的目的,但地佐辛引起恶心呕吐的发生率较布托啡诺高。
Objective To compare the adjuvant effect of butorphanol and dizocine in the resection of benign breast tumors under general anesthesia.Methods 90 patients who underwent benign breast tumor resection under general anesthesia in Foshan First People’s Hospital from January 2019 to December 2019 were randomly divided into group A (butorphanol),group B (dizocine) and group C (0.9% sodium chloride injection),with 30 patients in each group.On the basis of simple propofol intravenous general anesthesia,group A was slowly injected with butorphanol 10 μg·kg^(-1),dizocine 0.1 mg·kg^(-1) was slowly injected intravenously in group B,and 0.9% sodium chloride injection of the same volume was injected intravenously in group C.The mean arterial pressure (MAP),heart rate (HR),pulse oxygen saturation (SpO_(2)),postoperative awake time,postoperative analgesia score,total dosage of propofol and adverse reactions were observed in 3 groups at each intraoperative time point.Results The HR of group C was significantly higher than that of group A and group B (P < 0.05);The postoperative awake time in groups A and B was shorter than that in group C,the analgesic score 30 minutes after operation was lower than that in group C,and the total dosage of propofol was lower than that in group C (P < 0.05).Conclusion Single benign breast tumor resection with butorphanol or dezocine assisted propofol non intubated intravenous general anesthesia can reduce the incidence of intraoperative adverse reactions.The postoperative awake time is shorter than that in propofol intravenous general anesthesia group.The adverse reactions between the two groups have no serious consequences,and can be alleviated by human intervention;The application of butorphanol or dezocine can significantly reduce the postoperative pain and achieve the purpose of rapid recovery,but the incidence of nausea and vomiting caused by dezocine is higher than that of butorphanol.
作者
李露君
李世杰
张瑜
LI Lu-jun;LI Shi-jie;ZHANG Yu(Foshan First People's Hospital,Guangdong Foshan 528000)
出处
《深圳中西医结合杂志》
2021年第20期138-140,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
