摘要
同型半胱氨酸作为脑卒中的独立危险因素,与卒中发病率、复发率及预后均密切相关,在不同的卒中亚型中水平各有差异,致病机制主要涉及血管内皮损伤、平滑肌细胞增生、凝血及脂肪代谢异常等多个方面。同型半胱氨酸水平受基因型及代谢、年龄、性别、药物等多种因素影响,补充B族维生素及叶酸能显著降低同型半胱氨酸水平,降低高危人群的同型半胱氨酸水平对脑血管病的二级预防具有重要意义。本文针对同型半胱氨酸水平与脑卒中及其亚型、严重程度的相关性,在脑卒中发病机制中的作用以及治疗现状等方面进行综述,旨在为脑卒中临床预防及治疗提供参考。
Homocysteine,as an independent risk factor for stroke,is closely related to the incidence,recurrence rate and prognosis of stroke.Homocysteine level varies in different stroke subtypes,and the pathogenesis mainly involves vascular endothelial injury,hyperplasia of smooth muscle cells,coagulopathy,and abnormal fat metabolism.Homocysteine level is affected by genotype,metabolism,age,gender,drugs and other factors.Supplementation with B vitamins and folic acid can significantly reduce homocysteine level,which is important for secondary prevention of cerebrovascular disease.In this study,the correlation between homocysteine level and stroke,subtype and severity,and the role of homocysteine in the pathogenesis of stroke,and the treatment status were reviewed to provide references for clinical prevention and treatment.
作者
张鸥
刘洋
蒙航娟
丛树艳
ZHANG Ou;LIU Yang;MENG Hang-juan(Shengjing Hospital of China Medical Unversity,Shenyang,Liaoning Proince,110004,China)
出处
《中国公共卫生》
CSCD
北大核心
2021年第12期1840-1844,共5页
Chinese Journal of Public Health
