摘要
目的探讨中医药治疗冠脉微循环障碍(CMD)的用药规律。方法检索中国知网、中国生物医学文献数据库、PubMed和Cochrane Library等数据库中有关中医药治疗CMD的文献。将筛选后获得的方药建立数据库,应用频数统计、关联规则和聚类分析等数据挖掘方法总结其用药规律。结果最终获得89篇文献,处方90首,涉及中药131味。使用频次较高的中药有丹参、黄芪、川芎、当归、甘草、三七等;应用较多的中药种类有补虚药、活血化瘀药、理气药;四气以温、寒、平为主,五味多用甘、辛、苦;药物归经频次较高的依次为肝、脾、心经。关联规则分析得到核心药对是"丹参-黄芪",核心组合为"黄芪-川芎-丹参"。聚类分析将高频药物分为7类,以血府逐瘀汤、逍遥散、瓜蒌薤白半夏汤的加减组方为主,以及单味中药水蛭和人参。结论治疗CMD的核心药物为丹参、黄芪、川芎、当归,以益气活血,理气止痛为基本治法,兼以疏肝健脾、化痰通络等进行配伍。临床上可应用血府逐瘀汤、逍遥散、瓜蒌薤白半夏汤等经典名方随证加减治疗CMD。
Objective To analyze the medication rules of traditional Chinese medicine(TCM)in treating coronary microcirculation dysfunction(CMD).Methods The literatures on the treatment of CMD with TCM were searched from CNKI,PubMed,etc.,and the selected prescriptions were input into Microsoft Excel,for establishing the database.Using data mining method,frequency statistics,association rule,and cluster analysis were carried out to summarize rules of drug application.Results 89 literatures,90 prescriptions and 131 traditional Chinese medicines were collected.The most frequently used traditional Chinese medicines were Salviae miltiorrhizae radix et rhizoma,Astragali radix,Chuanxiong rhizome,Angelicae sinensis radix,Glycyrrhizae radix et rhizome,and Notoginseng radix et rhizoma,etc.The most effective drugs were those have the efficacies including replenishing deficiency,promoting blood circulation and removing blood stasis,regulating qi.Natures of the drugs were mainly warm,cold,mild.The flavors were mainly sweet,spicy,and bitter.The channel tropisms with more frequencies were the liver,the spleen,and the heart meridians.Owing to correlation analysis,the core drug pair was “Salviae miltiorrhizae radix et rhizoma-Astragali radix”,and the core combination was “Astragali radix-Chuanxiong rhizome-Salviae miltiorrhizae radix et rhizoma”.Cluster analysis of the high-frequency drugs showed that 7 groups were clustered,which mainly included Xuefu Zhuyu decoction,Xiaoyao san,Gualou Xiebai Banxia decoction,and modification usages of them,as well as single Chinese medicine Hirudo,and Ginseng radix et rhizoma.Conclusion The core drugs for the treatment of CMD are Salviae miltiorrhizae radix et rhizoma,Astragali radix,Chuanxiong rhizome,Angelicae sinensis radix.The main treatment principles are nourishing qi and promoting blood circulation,regulating qi and relieving pain,and they are combined with soothing the liver and invigorating the spleen,dissolving phlegm and dredging collaterals.According to the syndrome,the famous classic prescriptions such as Xuefu Zhuyu decoction,Xiaoyao san,Gualou Xiebai Banxia decoction could be added or subtracted in the treatment of coronary microcirculation disorders.
作者
龚胜兰
范雅雯
牟雷
朱瑾娴
丘雪莹
吴玮
赵杰
张天奉
GONG Shenglan;FAN Yawen;MU Lei;ZHU Jinxian;QIU Xueying;WU Wei;ZHAO Jie;ZHANG Tianfeng(Shenzhen Hospital of Guangzhou University of Chinese Medicine(Futian),Shenzhen 518034 Guangdong,China;The Sixth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518034 Guangdong,China;Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2021年第11期1731-1736,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金项目(81774182)
广东省中医药局科研项目(20181232,20201419)。
关键词
中医药
冠脉微循环障碍
数据挖掘
用药规律
关联规则
聚类分析
Traditional Chinese medicine
coronary microvascular disease
data mining
medication rule
association rules
clustering analysis
