摘要
目的:研究用更昔洛韦联合丙种球蛋白治疗小儿传染性单核细胞增多症的效果。方法:将60例传染性单核细胞增多症患儿随机分为对照组和观察组。对照组患儿使用更昔洛韦进行治疗,观察组患儿使用更昔洛韦联合丙种球蛋白进行治疗,然后比较两组患儿的疗效及各项临床指标。结果:治疗后,观察组患儿退热的时间、肝脾肿大消退的时间、咽峡炎症状消失的时间和颈部淋巴结肿大消退的时间均短于对照组患儿,P<0.05。观察组患儿治疗的总有效率高于对照组患儿,P<0.05。治疗后,观察组患儿血清谷丙转氨酶(ALT)、谷草转氨酶(AST)的水平和白细胞(WBC)计数均低于对照组患儿,P<0.05。用药后,两组患儿不良反应的发生率相比,P>0.05。结论:用更昔洛韦联合丙种球蛋白治疗小儿传染性单核细胞增多症的效果显著,能快速缓解患儿的临床症状,改善其血清ALT、AST的水平,减轻其机体的炎症反应,且治疗的安全性较高。
Objective:To study the effect of ganciclovir combined with gamma globulin in the treatment of infantile infectious mononucleosis.Methods:60 children with infectious mononucleosis were randomly divided into control group and observation group.The control group was treated with ganciclovir,and the observation group was treated with ganciclovir combined with gamma globulin,and then the efficacy and clinical indicators of the two groups were compared.Results:After treatment,the time of fever reduction,the time of hepatosplenomegaly regression,the time of angina inflammation disappearance and the time of cervical lymph node enlargement regression in the observation group were shorter than those in the control group,P<0.05.The total effective rate of observation group was higher than control group,P<0.05.After treatment,the serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels and white blood cell(WBC)count in the observation group were lower than those in the control group,P<0.05.After medication,the incidence of adverse reactions between the two groups was compared,P>0.05.Conclusion:Ganciclovir combined with gamma globulin has a significant effect on the treatment of infantile infectious mononucleosis,which can quickly relieve the clinical symptoms,improve the levels of ALT and AST in serum,and reduce the inflammatory response of the body,with high safety.
作者
王璇
姚燕娜
WANG Xuan;YAO Yanna(Xi'an Gaoling District Maternal and Child Health Hospital,Xi'an Shaanxi 710200)
