摘要
白塞病(Behcet’s disease,BD)是一种系统性炎症性疾病,临床上以口腔、外阴溃疡和葡萄膜炎为主要表现。病理表现为累及各种血管管径的血管炎,有血栓倾向。BD发病机制不明,除环境和遗传因素外,T细胞免疫应答异常也参与发病,涉及固有免疫的γδT细胞、特性抗原的识别、抗原呈递及以CD4+、CD8+T细胞为代表的适应性免疫。T细胞稳态失衡主要表现为Th1、Th17辅助T细胞的活化、增殖和Treg细胞损伤。上述免疫应答异常诱导和维持BD的促炎环境。本文围绕T细胞亚群参与BD的免疫应答特征、T细胞亚群参与免疫介导炎症反应以及治疗的转化和未来的靶向进行综述。
Behcet’s disease(BD)is a systemic inflammatory disorder characterized by orogenital ulcerations and uveitis.Pathology of BD suggests a vasculitis with mixed-cellular perivascular infiltrates and thrombotic tendency.Its pathogenesis is obscure.Environmental agent,genetic predisposition and immune-dysregulation involving T cells are reported to have a role in the pathogenesis of BD,which includesγδT cells featuring innate immunity,recognition of specific antigens,antigen presenting,CD4+T cells and CD8+T cells featuring adaptive immunity.Th1/Th17 expansion and Treg impairment are the central futures of altered T-cell homeostasis.All of those have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of BD.Here,we review the features of the phenotypes of T cell subsets in BD,by which modify the immune conducted inflammation,and the transformation of treatment and future target therapy.
作者
邹峻(综述)
管剑龙(审校)
ZOU Jun;GUAN Jian-long(Department of Rheumatology and Immunology,Huadong Hospital,Fudan University,Shanghai 200040,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2022年第1期114-118,共5页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金面上项目(81871276)。
