摘要
目的探讨实时剪切波弹性成像联合血清microRNA-10b(miR-10b)表达量预测先兆子痫的应用价值。方法 120例疑似先兆子痫孕妇根据子痫前期诊断标准分为先兆子痫孕妇35例(观察组)和正常孕妇85例(对照组),均行实时剪切波弹性成像和血清miR-10b检查,比较两组胎盘各部位弹性模量值和血清miR-10b表达量。分析胎盘弹性模量值与血清miR-10b表达量的相关性。绘制受试者工作特征(ROC)曲线评估胎盘弹性模量值、miR-10b表达量及其联合预测先兆子痫的效能。结果观察组胎盘中央部位、边缘部位的弹性模量值均高于对照组,而血清miR-10b表达量低于对照组,差异均有统计学意义(均P<0.05)。相关性分析显示,胎盘中央部位、边缘部位弹性模量值与血清miR-10b表达量均呈负相关(r=-0.445、-0.437,均P<0.05)。ROC曲线分析显示,胎盘中央部位、边缘部位弹性模量值、血清miR-10b表达量及其联合预测先兆子痫的曲线下面积分别为0.821、0.865、0.772、0.985,敏感性分别为51.4%、60.0%、100%、94.3%,特异性分别为100%、97.6%、50.6%、100%;联合应用的曲线下面积高于各方法单独应用(均P<0.05)。结论实时剪切波弹性成像联合血清miR-10b表达量在预测先兆子痫中具有较高价值,能为临床诊断提供参考信息。
Objective To explore the value of real-time shear wave elastography combined with serum microRNA-10 b(miR-10 b)expression level in predicting preeclampsia.Methods Totally 120 pregnant women with suspected preeclampsia were divided into 35 cases of preeclampsia(observation group) and 85 cases of normal pregnant women(control group)according to diagnostic standard of preaclampsia.Real-time shear wave elastography and serum miR-10 b were detected,the elastic modulus value in different part of the placenta and serum miR-10 b expression level between the two groups were compared.The correlation between placenta elastic modulus value and serum miR-10 b expression level was analyzed.Receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic efficacy of placenta elastic modulus value,serum miR-10 b expression level and their combination in predicting preeclampsia.Results The placenta elastic modulus value the at center and edge of the observation group were higher than those of the control group,while the serum miR-10 b expression level was lower than that of the control group,there were significant differences(all P<0.05).Correlation analysis showed that the placenta elastic modulus value at center and edge were negatively correlated with serum miR-10 b expression level(r=-0.445,-0.437,both P<0.05).ROC curve analysis showed that the area under the curve of elastic modulus value at the center and edge,serum miR-10 b expression level,and their combination were 0.821,0.865,0.722,0.985,respectively.The sensitivity were51.4%,60.0%,100%,94.3%,the specificity were 100%,97.6%,50.6%,100%.The area under the curve of combination was higher than that of application alone(all P<0.05).Conclusion Real-time shear wave elastography combined with serum microRNA-10 expression level has high value in predicting preeclampsia,and can provide reference for clinical diagnosis.
作者
姚路
丁燕燕
马红云
白蓉
马宗丽
YAO Lu;DING Yanyan;MA Hongyun;BAI Rong;MA Zongli(Department of Obstetrics,Rugao People’s Hospital of Jiangsu Province,Jiangsu 226500,China)
出处
《临床超声医学杂志》
CSCD
2021年第12期920-923,共4页
Journal of Clinical Ultrasound in Medicine
