摘要
目的:观察乙型肝炎(HB)患者细胞免疫功能的变化与病毒复制的关系。方法:选取尉氏县人民医院2018年8月至2019年8月收治的160例HB患者为研究对象,按照HB患者病毒复制不同将患者分为A组(80例,HBV–DNA载量检测结果大于1.0×10^(5) copy·mL^(-1))与B组(80例,HBV–DNA载量检测结果在1.0×10^(3)~1.0×10^(5) copy·mL^(-1)),比较两组患者免疫功能、细胞因子及肝功能相关参数变化情况。结果:A组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)等免疫功能相关参数均低于B组,差异具有统计学意义(P<0.05)。A组白细胞介素(IL)–4、IL–6、IL–9、IL–10等细胞因子以及谷丙转氨酶(ALT)、天冬氨酸氨基转移酶(AST)、γ–谷氨酰转移酶(γ–GT)、总胆红素(TBiL)等肝功能参数均高于B组,差异具有统计学意义(P<0.05)。结论:HB病毒复制增加可进一步加重患者细胞免疫功能紊乱、降低个体肝功能。
Objective To observe the relationship between changes in cellular immune function and virus replication in patients with hepatitis B(HB).Methods A total of 160 HB patients who were admitted to Weishi County People’s Hospital from August 2018 to August 2019 were selected as the research objects.The patients were divided into group A(80 cases)and group B(80 cases),compare the clinical treatment effects of immune function cytokine and the related parameters of liver function between the two groups.Results The CD3^(+)、CD4^(+)and CD4^(+)/CD8^(+)of group A were lower than those of group B,the differences were statistically significant(P<0.05).Interleukin-4(IL-4),IL-6,IL-9,IL-10 and other cytokines,liver functions such as alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyltransferase(γ-GT),and total bilirubin(TBiL)of group A were all higher than those of group B,and the differences were statistically significant Significance(P<0.05).Conclusion Increased HB virus replication can further aggravate cellular immune dysfunction and reduce individual liver function.
作者
孙坤
王海江
张恒
SUN Kun;WANG Hai-jiang;ZHANG Heng(Weishi County People's Hospital,Henan Weishi 475500)
出处
《深圳中西医结合杂志》
2021年第19期28-30,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
乙型肝炎
细胞免疫功能
病毒复制
Hepatitis B
Cellular immune function
Virus replication
