摘要
颅内动脉瘤(intracranial aneurysm,IA)是颅内动脉血管因先天异常或后天损伤等因素导致局部的血管壁扩张,在血流动力学负荷和其他因素作用下,IA逐渐发展乃至破裂引发蛛网膜下腔出血,引起严重的精神症状甚至危及生命。其发病机制复杂,可能与细胞损伤的继发反应关系密切,同时该过程还受炎症反应影响而加重。提出通过抑制炎症反应阻断动脉瘤发生发展过程的中下游环节,从而阻止或延缓IA的发生发展,降低破裂风险的潜在干预策略;自噬与凋亡二者对血管平滑肌细胞表型转换有协同作用,此过程可能为治疗IA的潜在机制。将中药对心脑血管病调控平滑肌细胞的表型转化和自噬、调控炎症通路的机制进行梳理和挖掘,对中药作为延缓IA发生和发展的治疗策略进行展望。
Intracranial aneurysm(IA)is a gradual expansion of intracranial arteries caused by congenital abnormalities or acquired injuries.It’s an abnormal bulge due to the load of hemodynamics and other factors.The aneurysm gradually develops and even ruptures causing subarachnoid hemorrhage,and that can cause severe psychiatric symptoms and even life-threatening.It has complicated pathogenesis.The latest research shows that the occurrence of IA may be closely related to the secondary reaction of cell injury,and the process is getting aggravated affected by inflammation.Article proposes a potential intervention strategy which is blocking the middle and downstream links of inflammatory response to delay the occurrence and development of IA,and to reduce the risk of IA’s rupture;Both autophagy and apoptosis have an effect on the phenotype of vascular smooth muscle cells,this synergistic effect may be a potential mechanism for the treatment of IA.The article prospects the treatment strategy of TCM,by exploring the mechanism of TCM in regulating phenotype transformation and autophagy in smooth muscle cells,and regulating inflammatory pathways for cardiovascular and cerebrovascular diseases were sorted out and summarized respectively.
作者
吴恺怿
张琳
黄娜娜
林佳坤
孙蓉
WU Kai-yi;ZHANG Lin;HUANG Na-na;LIN Jia-kun;SUN Rong(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;The Second Hospital of Shandong University,Jinan 250033,China;Tianjin University of Traditional Chinese Medicine(TCM),Tianjin 301617,China;Advanced Medical Research Institute,Shandong University,Jinan 250012,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第21期6732-6742,共11页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金面上项目(81773997)
山东省自主创新和成果转化项目(2014ZZCX02104)
泰山学者工程专项经费项目(ts201511107)。
关键词
颅内动脉瘤
炎症
自噬
凋亡
中药治疗策略
intracranial aneurysm
inflammation
autophagy
apoptosis
TCM treatment strategies
