摘要
目的:观察噻托溴铵粉联合多索茶碱治疗慢性阻塞性肺疾病(慢阻肺)患者的效果。方法:选取90例慢阻肺患者作为研究对象,按照随机数字表法分为观察组与对照组各45例。对照组给予多索茶碱注射液治疗,观察组在对照组基础上联合噻托溴铵粉雾剂治疗,比较两组疗效、肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC,平均肺动脉压(MPAP)、肺动脉舒张压(PADP)和肺动脉收缩压(PASP)]水平和不良反应发生率。结果:观察组治疗总有效率为95.56%,明显高于对照组的82.22%,差异有统计学意义(P<0.05);治疗后,两组FEV_(1)、FVC和FEV_(1)/FVC水平均高于治疗前,且观察组高于对照组,两组MPAP、PADP和PASP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:噻托溴铵粉联合多索茶碱治疗慢阻肺患者可提高治疗总有效率,改善患者肺功能指标水平,效果优于单纯多索茶碱治疗。
Objective:To observe effects of Tiotropium bromide powder combined with Doxofylline in treatment of patients with chronic obstructive pulmonary disease.Methods:90 patients with chronic obstructive pulmonary obstruction were selected as the research objects,and were divided into observation group and control group according to the random number table method,45 cases in each group.The control group was treated with Doxofylline injection,while the observation group was treated with Tiotropium bromide powder spray on the basis of that of the control group.The efficacy,the pulmonary function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC,mean pulmonary artery pressure(MPAP),pulmonary artery diastolic blood pressure(PADP)and pulmonary artery systolic pressure(PASP)]and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.56%,which was significantly higher than 82.22%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV_(1),FVC and FEV_(1)/FVC in the two groups were higher than those before the treatment,and those of the observation group were higher than those of the control group;the MPAP,PADP and PASP levels in the two groups were lower than those before the treatment,and those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tiotropium bromide powder combined with Doxofylline in the treatment of the patients with chronic obstructive pulmonary disease can increase the total effective rate of treatment and improve the levels of the pulmonary function indicators.Moreover,it is superior to single Doxofylline treatment.
作者
孙茜
SUN Xi(Department of Respiratory Diseases of the Central Hospital of Jiamusi City,Jiamusi 154002 Heilongjiang,China)
出处
《中国民康医学》
2021年第21期10-11,14,共3页
Medical Journal of Chinese People’s Health
关键词
慢性阻塞性肺疾病
多索茶碱
噻托溴铵粉
肺功能
不良反应
Chronic obstructive pulmonary disease
Doxofylline
Tiotropium bromide Powder
Pulmonary function
Adverse reaction
