摘要
目的观察散结消肿方联合甲泼尼龙治疗非哺乳期乳腺炎(NPM)肿块期对患者泌乳素(PRL)、自然杀伤细胞(NK)水平的影响。方法选取宝鸡市中医医院2018年7月至2020年5月收治的NPM肿块期患者114例,根据随机数表法分为观察组和对照组,每组57例。对照组患者给予甲泼尼龙治疗,观察组给予散结消肿方联合甲泼尼龙治疗,两组均连续治疗12周。比较两组患者治疗前、治疗12周后的症状体征积分、肿块面积,检测两组患者治疗前、治疗12周后的外周血中性粒细胞(N)、NK、树突状细胞1(DC1)、树突状细胞2(DC2)细胞水平及PRL、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平。结果治疗后,观察组和对照组患者的乳房疼痛积分[(0.56±0.22)分vs(0.95±0.25)分]、红肿积分[(0.71±0.31)分vs(1.05±0.28)分]、肿物积分[(0.64±0.26)分vs(0.85±0.34)分]、脓肿积分[(0.34±0.19)分vs(0.51±0.22)分]、瘘管积分[(0.41±0.18)分vs(0.58±0.21)分]、乳头凹陷积分[(1.12±0.27)分vs(1.36±0.35)分]、肿块面积[(2.97±0.41)cm^(2)vs(3.64±0.45)cm2]比较,观察组上述症状体征积分及肿块面积明显低(少)于对照组,差异均有统计学意义(P<0.05);治疗后,观察组和对照组患者的外周血DC1[(1.98±0.29)%vs(1.86±0.31)%]水平比较,观察组明显高于对照组,N[(66.42±4.31)%vs(72.86±4.27)%]、NK[(16.52±0.79)%vs(17.41±0.98)%]、DC2[(2.11±0.15)%vs(2.18±0.17)%]水平比较,观察组明显低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组和对照组患者的PRL[(19.86±2.18)ng/mL vs(23.57±2.34)ng/mL]、CRP[(11.47±3.26)mg/L vs(15.22±4.51)mg/L]、IL-6[(128.96±24.75)ng/L vs(146.86±31.17)ng/L]水平比较,观察组明显低于对照组,差异均有统计学意义(P<0.05)。结论散结消肿方联合甲泼尼龙治疗NPM肿块期可减轻患者的症状和体征,改善机体免疫功能和泌乳素的分泌,减轻炎症反应,缩小肿块面积。
Objective To observe the effect of Sanjie Xiaozhong prescription combined with methylprednisolone on the levels of prolactin(PRL)and natural killer cells(NK)in patients with non-puerperal mastitis(NPM)of mass stage.Methods A total of 114 patients with NPM of mass stage admitted to Baoji Hospital of Traditional Chinese Medicine from July 2018 to May 2020 were selected and divided into an observation group and a control group according to random number table method,with 57 patients in each group.Patients in the control group were treated with methylprednisolone,and those in the observation group were treated with Sanjie Xiaozhong prescription combined with methylprednisolone.Both groups were treated for 12 weeks.The symptoms and signs scores and tumor area were compared between the two groups before treatment and after 12 weeks of treatment.Peripheral blood neutrophils(N),NK,dendritic cells 1(DC1),Dendritic cell 2(DC2)level and changes in PRL,C-reactive protein(CRP),and interleukin-6(IL-6)were detected before treatment and after 12 weeks of treatment.Results After treatment,the observation group were significantly lower(less)than the control group in the following indexes(P<0.05):breast pain score,(0.56±0.22)points vs(0.95±0.25)points;swelling score,(0.71±0.31)points vs(1.05±0.28)points;tumor score,(0.64±0.26)points vs(0.85±0.34)points;abscess score,(0.34±0.19)points vs(0.51±0.22)points;fistula score,(0.41±0.18)points vs(0.58±0.21)points;nipple depression score,(1.12±0.27)points vs(1.36±0.35)points;mass area,(2.97±0.41)cm2 vs(3.64±0.45)cm^(2).After treatment,the peripheral blood DC1 cells levels of the observation group were significantly higher that in the control group:(1.98±0.29)%vs(1.86±0.31)%;N cells,NK cells,DC2 cells level of the observation group were significantly lower those in the control group:N cells,(66.42±4.31)%vs(72.86±4.27)%;NK cells,(16.52±0.79)%vs(17.41±0.98)%;DC2 cells,(2.11±0.15)%vs(2.18±0.17)%;the differences were statistically significant(P<0.05).After treatment,PRL,CRP,IL-6 of the observation group were significantly lower than those in the control group(P<0.05):PRL,(19.86±2.18)ng/mL vs(23.57±2.34)ng/mL;CRP,(11.47±3.26)mg/L vs(15.22±4.51)mg/L;IL-6,(128.96±24.75)ng/L vs(146.86±31.17)ng/L.Conclusion Combined with methylprednisolone,Sanjie Xiaozhong prescription can relieve symptoms and signs in patients with NPM of mass stage,improve immune function and secretion of prolactin,relieve inflammatory reaction,and reduce mass area.
作者
张丽芳
张汉新
ZHANG Li-fang;ZHANG Han-xin(Medical Cosmetology Department,Baoji Hospital of Traditional Chinese Medicine,Baoji 721000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2021年第22期2868-2871,共4页
Hainan Medical Journal
关键词
非哺乳期乳腺炎
肿块期
散结消肿方
甲泼尼龙
泌乳素
免疫功能
Non-puerperal mastitis
Mass stage
Sanjie Xiaozhong prescription
Methylprednisolone
Prolactin
Immune function
