摘要
目的:探讨扶元乳膏肾俞穴位敷贴对围绝经期骨量减少女性MAPK信号通路的影响。方法:选取63例围绝经期骨量减少女性作为研究对象,将其随机分为观察组(32例)和对照组(31例)。对照组给予激素替代治疗;观察组给予扶元乳膏肾俞穴位敷贴治疗。收集两组的血清,采用化学发光免疫分析法测定FSH、IL-1β、TNF-α,采用荧光定量PCR测定ERK、p38、JNK基因水平。结果:干预前两组血清中FSH、IL-1β、TNF-α、ERK、p38、JNK差别无统计学意义(P>0.05),干预后上述六项指标差别有统计学意义(P<0.05)。结论:扶元乳膏肾俞穴位敷贴能改善围绝经期女性骨代谢和提高骨密度,其作用机制可能与其降低患者血清中IL-1β和TNF-α的水平,与双向良性调控MAPK信号传导途径有关。
Objective:To investigate the effect of Shenshu acupoint application of Fuyuan Cream on MAPK signal pathway in perimenopausal women with osteopenia.Methods:63 women with perimenopausal Osteopenia were randomly divided into observation group(32 cases) and control group(31 cases).The control group was given Hormone Replacement Therapy,the observation group was given Fu Yuan Cream Shenshu acupoint application therapy.Serum samples of the two groups were collected and the levels of FSH、IL-1β、TNF-α,while ERK、p38、JNK were measured by fluorescence quantitative PCR.Result:There were no significant differences in serum FSH、IL-1β、TNF-α,ERK、p38 and JNK between the two groups before intervention(P>0.05).After intervention,the difference of the above six indexes was statistically significant(P<0.05).Conclusion:Fuyuan Cream Shen Shu point application can improve bone metabolism and increase bone mineral density in perimenopausal women.The mechanism may be related to the decrease of serum levels of IL-1β and TNF-α,and the regulation of two-way Benign MAPK signal transduction pathway.
作者
刘汉娇
陈柏书
李映渊
LIU Han-jiao;CHEN Bai-shu;LI Yin-yuan(Shenzhen Baoan District Hospital of Traditional Chinese medicine,Guangdong Shenzhen 518133)
出处
《按摩与康复医学》
2021年第21期38-40,共3页
Chinese Manipulation and Rehabilitation Medicine
基金
广东省中医药局资助项目(20181236)。
