摘要
目的对比阿立哌唑与利培酮治疗首发女性精神分裂症患者的临床效果。方法选取2018年3月—2020年3月于该院所收治的146例首发女性精神分裂症患者为研究对象,将其随机分为利培酮组与阿立哌唑组,每组73例。分别行利培酮与阿立哌唑治疗,比较两组患者的临床疗效与不良反应的发生情况。结果两组患者的临床治疗总有效率比较(93.15%vs 90.41%),差异无统计学意义(χ^(2)=0.363,P>0.05),治疗前后两组的PANSS总分比较差异无统计学意义(P﹥0.05);阿立哌唑组患者不良反应的发生率较利培酮组更低,差异有统计学意义(P<0.05);利培酮组患者治疗后的体质量与PRL水平明显上升,且明显高于阿立哌唑组,差异有统计学意义(t=7.578、25.159,P<0.05)。结论阿立哌唑与利培酮治疗首发女性精神分裂症的临床疗效均较好,但阿立哌唑不良反应的发生较少,安全性较好,且对患者体质量与PRL的影响较小,更适合女性患者使用。
Objective To compare the clinical effects of aripiprazole and risperidone in the treatment of first-episode female schizophrenia.Methods A total of 146 first-episode female schizophrenia patients admitted to the hospital from March 2018 to March 2020 were selected as research objects and randomly divided into risperidone group and aripiprazole group,with 73 patients in each group.Risperidone and aripiprazole were used respectively to compare the clinical efficacy and the incidence of adverse reactions between the two groups.Results The total effective rate of clinical treatment between the two groups of patients was compared(93.15%vs 90.41%),and the difference was not statistically significant(χ^(2)=0.363,P>0.05).There was no statistically significant difference in the total PANSS scores of the two groups before and after treatment(P>0.05);the incidence of adverse reactions in the aripiprazole group was lower than that%in the risperidone group,and the difference was statistically significant(P<0.05);the quality and PRL level increased significantly,and were significantly higher than the aripiprazole group,the difference was statistically significant(t=7.578,25.159,P<0.05).Conclusion Both aripiprazole and risperidone have good clinical efficacy in the treatment of first-episode female schizophrenia,but aripiprazole has fewer adverse reactions,better safety,and less impact on patient body quality and PRL,so it is more suitable for female patients.
作者
王万军
WANG Wanjun(Department of Psychiatry,Mental Health Center of Rizhao City,Rizhao,Shandong Province,276800 China)
出处
《系统医学》
2021年第17期4-7,共4页
Systems Medicine
