摘要
目的:探讨异甘草酸镁联合门冬氨酸鸟氨酸治疗乙肝肝硬化肝性脑病患者的效果。方法:回顾性分析2019年6月至2020年12月该院收治的84例乙肝肝硬化肝性脑病患者的临床资料,按治疗方法不同分为对照组和研究组各42例。对照组采用注射用门冬氨酸鸟氨酸治疗,研究组在对照组基础上联合异甘草酸镁治疗。比较两组临床疗效、治疗前后肝功能指标水平及不良反应发生率。结果:研究组治疗总有效率为95.24%(40/42),高于对照组的76.19%(32/42),差异有统计学意义(P<0.05);治疗后,研究组血氨、总胆红素、丙氨酸氨基转移酶水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:异甘草酸镁联合门冬氨酸鸟氨酸治疗乙肝肝硬化肝性脑病患者效果确切,可降低血氨水平,改善肝功能,效果优于单用门冬氨酸鸟氨酸。
Objective:To observe effects of Magnesium isoglycyrrhizinate combined with Ornithine aspartate in treatment of patients with hepatitis B liver cirrhosis and hepatic encephalopathy.Methods:A retrospective analysis of the clinical data of 84 patients with hepatitis B cirrhosis and hepatic encephalopathy admitted to our hospital from June 2019 to December 2020 was performed.According to different treatment methods,they were divided into control group and study group,each with 42 cases.The control group was given Ornithine aspartate for injection,while the study group was combined with Magnesium isoglycyrrhizinate injection on the basis of that of the control group.The clinical efficacy,the liver function index levels and the occurrence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 95.24%(40/42),which was higher than 76.19%(32/42)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the blood ammonia,total bilirubin,and alanine aminotransferase levels in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,the incidence rates of adverse reactions in the two groups were similar,and the difference was not statistically significant(P>0.05).Conclusions:Magnesium isoglycyrrhizinate combined with Ornithine aspartate is effective in the treatment of the patients with hepatitis B cirrhosis and hepatic encephalopathy,which can reduce the blood ammonia levels and improve the liver function.Moreover,it is superior to single Ornithine aspartate.
作者
张志娟
ZHANG Zhijuan(Central Hospital of Harqin Left Wing Mongolian Autonomous County,Chaoyang 122300 Liaoning,China)
出处
《中国民康医学》
2021年第20期36-38,共3页
Medical Journal of Chinese People’s Health
关键词
乙肝肝硬化
肝性脑病
门冬氨酸鸟氨酸
异甘草酸镁
肝功能
安全性
Hepatitis B cirrhosis
Hepatic encephalopathy
Ornithine aspartate
Magnesium isoglycyrrhizinate
Liver function
Safety
