摘要
糖尿病分型是指导临床决策的重要依据,世界卫生组织(WHO)在1965年首次对糖尿病进行分型,并先后进行了4次更新,这些分型的演变不仅在一定程度上体现了半个多世纪以来对于糖尿病发病机制和临床发展结局认识的深入,同时也更好地应对了临床实际需求,增加了分型的灵活性、可操作性和动态演变性。鉴于糖尿病本身的复杂性和异质性,以及对糖尿病认识的局限性,目前的糖尿病分型还有很多未能满足的临床需求。结合糖尿病的病理生理学基础、临床表型、并发症的易感性、对药物的反应性和基因分子诊断等特征的精准分型,是未来糖尿病分型的发展方向。由单一基因突变所致的单基因糖尿病为糖尿病个体化精准管理提供了一个良好范例。
The classification of diabetes provides an important basis for clinical decision of diabetes management. World Health Organization(WHO)announced the first diabetes classification in 1965, and has updated it four times over the past half century. These updates not only reflected the better understanding of diabetes pathogenesis and clinical outcomes, but also highlighted the importance of clinical needs for the management of diabetes. However, the classification systems are clearly limited by significant knowledge gaps and available resources for diabetes management. Therefore, the most updated WHO classification of diabetes prioritizes clinical care to guide health professionals choose appropriate treatments, particularly at the time of diagnosis. There are significant unmet clinical needs for classification of diabetes. Accumulating evidence indicates that monogenic diabetes appears to be the best clinical model for precise medicine and individualized management of diabetes.
作者
舒画
杨迎
李新
刘铭
Shu Hua;Yang Ying;Li Xin;Liu Ming(Department of Endocrinology and Metabolism,the General Hospital of Tianjin Medical University,Tianjin 300050,China)
出处
《国际内分泌代谢杂志》
2021年第5期413-417,共5页
International Journal of Endocrinology and Metabolism
基金
天津市科技计划项目(2020KJ47)。
关键词
糖尿病分型
单基因糖尿病
精准医学
Classification of diabetes
Monogenic diabetes
Precision medicine
