摘要
目的探讨儿童外周血中性粒细胞减少的临床特征以及相关因素,为其防治提供依据。方法收集2017年10月—2019年10月因原发病就诊时发现中性粒细胞减少而确诊的住院病儿270例,对其临床资料、实验室检查、临床治疗及预后进行回顾性分析。结果 270例外周血中性粒细胞减少的病儿中,幼儿期占43.70%,学龄前期占32.59%;男女发病比例为1.18∶1;首发病中呼吸系统疾病占61.11%;病原体以病毒为主,其次为支原体及细菌;对症治疗后84.44%的病儿可于1周内恢复正常且临床症状完全消失;173例(64.07%)病儿外周血中性粒细胞数减少,白细胞总数未减少;97例(35.93%)病儿中性粒细胞数和白细胞总数同时减少。结论儿童外周血中性粒细胞减少以幼儿、学龄前期病儿为高发群体,多由病毒感染引起。加强病原学检测,正确使用抗病毒药物及抗生素,及时对症治疗可有效缩短其病程,改善病儿预后和抵抗力。
Objective To investigate the clinical features and related factors of peripheral blood neutropenia in children, and to a provide basis for its prevention and treatment. Methods A retrospective analysis was performed for the data of 270 hospitalized children who were diagnosed with neutropenia when attending the hospital due to primary diseases from October 2017 to October 2019, including clinical data, laboratory examination, clinical treatment, and prognosis. Results Among the 270 children with peripheral blood neutropenia, 43.70% had disease onset in infancy and 32.59% had disease onset at the preschool age. The male/female ratio was 1.18∶1. Respiratory diseases accounted for 61.11% of the initial diseases. Virus was the most common type of pathogen, followed by mycoplasma and bacteria. After symptomatic treatment, 84.44% of the children returned to normal and achieved complete disappearance of clinical symptoms within 1 week. Of all children, 173(64.07%) had a reduction in neutrophil count in peripheral blood, without reduction in total leukocyte count, and 97(35.93%) had reductions in both neutrophil count and total leukocyte count. Conclusion Peripheral blood neutropenia is mainly observed in infants and preschool-aged children and it is mostly caused by virus infection. Strengthening etiology detection and proper use of antiviral drugs and antibiotics, and timely symptomatic treatment can effectively shorten the course of the disease and improve children’s prognosis and resistance.
作者
王帅
刘广燕
姜忠信
胡川
刘成玉
WANG Shuai;LIU Guangyan;JIANG Zhongxin;HU Chuan;LIU Chengyu(Qingdao University Medical College,Qingdao 266071,China)
出处
《青岛大学学报（医学版）》
2021年第5期717-720,共4页
Journal of Qingdao University(Medical Sciences)
基金
教育部卫生部第一批卓越医生教育培养计划项目(教高函[2012]20号(92))。
