摘要
目的:观察超声热疗联合TPF化疗对老年晚期口腔鳞状细胞癌(OSCC)的疗效及安全性。方法:对2017年1月—2020年1月在徐州市中心医院口腔科就诊的19例OSCC老年患者,给予TPF化疗,周期第1天—多西他赛(75 mg/m^(2))+顺铂(75 mg/m^(2)),周期第1~5天—5,Fu(750 mg/m^(2));在化疗过程中做5次热疗,分别于化疗开始的第1、3、5、7、9天,超声热化疗共2个疗程,观察并评价效果。采用SPSS 20.0软件包进行统计学分析,利用Kaplan-Meire法计算生存率。结果:根据实体瘤评价标准1.0版,对肿瘤的变化进行疗效评价,其中完全缓解3例,部分缓解10例,疾病稳定5例,疾病进展1例,总有效率为68.4%。中位随访时间为36个月(8~48个月),2年内生存率为63.2%。不良反应主要表现为常规化疗反应,未见严重不良反应。结论:超声热疗联合化疗对老年口腔鳞癌患者具有协同抗肿瘤作用,安全有效,有望成为肿瘤治疗的又一种选择。
PURPOSE:To evaluate the efficacy and safety of ultrasound hyperthermia combined with TPF chemotherapy for advanced oral squamous cell carcinoma in the elderly.METHODS:Nineteen elderly patients who had definite pathological diagnosis were enrolled in this clinical trail from June 2017 to January 2020.Docetaxel(75 mg/m^(2))+cisplatin(75 mg/m^(2))were given on the 1 st day,and 5,Fu(750 mg/m^(2))on the 1 st to 5 th day of the cycle.Five times of hyperthermia were performed in the course of chemotherapy,respectively on the l,3,5,7 and 9 days after the beginning of chemother-apy.All patients received 2 cycles of thermo-chemotherapy.Statistical analysis was performed using SPSS 20.0 software package.Kaplan-Meire method was used to calculate survival rate.RESULTS:According to the efficacy evaluation standard for solid tumor(version 1.0),complete response(CR)was seen in 3 cases,partial response(PR)was seen in 10 cases,stable disease(SD)was seen in 5 cases,progressive disease(PD)was seen in 1 case.The overall responding rate was68.4%.The median follow-up time was 36 months(8-48 months),and the 2-year overall survival rates were 63.2%.No serious adverse reactions were observed.CONCLUSIONS:Ultrasound hyperthermic therapy combined with chemotherapy has a synergistic anti-tumor effect on patients with advanced oral squamous cell carcinoma,which is safe and effective,and is worthy of becoming another choice of tumor treatment.
作者
李蕾
李晓东
庄乾伟
葛良玉
李志萍
顾倩平
白玉婷
孟箭
LI Xiao-dong;ZHUANG Qian-wei;GE Liang-yu;LI Zhi-ping;GU Qian-ping;BAI Yu-ting;MENG Jian(School of Stomalology,Weifang Medical University,Weifang 261053,Shandong Province;Department of Stomatology,Xuzhou Central Hospital,Xuzhou 221000,Jiangsu Province,China)
出处
《上海口腔医学》
CAS
北大核心
2021年第5期543-547,共5页
Shanghai Journal of Stomatology
基金
徐州市重点研发计划(20210230)
江苏省卫生计生委科研课题(H2017080)
徐州市科技重点研发计划(KC17196)。
关键词
超声热疗
化疗
口腔鳞癌
老年
Ultrasound hyperthermia
Chemotherapy
Oral squamous cell carcinoma
Elderly patients
