摘要
目的:探究参芪麦味地黄汤联合阿卡波糖对糖耐量异常(IGT)患者血糖水平、体质量指数(BMI)及腹部脂肪厚度的影响。方法:将2017年2月至2019年1月成都市双流区第一人民医院收治的130例IGT患者纳入研究,应用随机数字表法将患者分为对照组(65例)和研究组(65例)。两组患者均给予饮食调理,运动锻炼常规治疗。对照组在常规治疗的基础上采用口服阿卡波糖治疗,研究组在对照组基础上加用参芪麦味地黄汤治疗。采用全血糖仪测量空腹血糖(FBG),口服葡萄糖耐量试验(OGTT)2 h血糖及糖化血红蛋白(HbA1c)水平;采用超声波断层法测定腹壁脂肪厚度;空腹取静脉血,测量血清总胆固醇(TC),甘油三酯(TG)及脂联素、瘦素水平。结果:治疗后,研究组和对照组的总有效率分别为95.38%(62/65),83.08%(54/65),研究组高于对照组(χ^(2)=5.175,P<0.05)。治疗前,两组IGT患者FBG,2 h OGTT水平,HbA1c,BMI,腰围,腹壁脂肪厚度,TC,TG,脂联素,瘦素比较,差异无统计学意义。治疗后,研究组和对照组IGT患者FBG,2 h OGTT水平,HbA1c,BMI,腰围,腹壁脂肪厚度,TC,TG,瘦素水平均低于治疗前(P<0.05),且研究组低于对照组(P<0.05,P<0.01);两组患者脂联素水平均高于治疗前(P<0.05),且研究组高于对照组(P<0.05)。结论:参芪麦味地黄汤联合阿卡波糖治疗糖耐量异常患者疗效显著,有效降低2 h OGTT水平,降低腹部脂肪厚度,缓解肥胖,改善患者体质。
Objective: To explore the effect of Shenqi Maiwei Dihuangtang(SQMWDH)combined with acarbose on the level of 2-hour oral glucose tolerance test(2 h OGTT),body mass index(BMI),and abdominal fat thickness in patients with impaired glucose tolerance(IGT). Method: A total of 130 patients with IGT admitted to the First People’s Hospital of Shuangliu District from February 2017 to January2019 were divided into a control group and a treatment group by a random number table. All patients received conventional treatment, such as diet regulation and exercise. The patients in the control group received additional oral administration of acarbose,while those in the treatment group were treated with SQMWDH based on the control group. Fasting blood glucose(FBG),2 h OGTT, and glycated hemoglobin A1 c(HbA1 c)levels were measured by the blood glucose meter. Abdominal fat thickness was measured by ultrasound tomography,and serum total cholesterol(TC),triglyceride(TG),adiponectin,and leptin levels in fasting venous blood were measured. Result:After treatment,the total response rate of the treatment group was higher than that of the control group(95.00% vs. 81.67%,χ^(2)=5.175,P<0.05). Before treatment,there was no significant difference in FBG,2 h OGTT,HbA1 c,BMI,waist circumference,abdominal fat thickness,TC,TG,adiponectin,and leptin of IGT patients between the two groups. After treatment,the levels of FBG,2 h OGTT,HbA1 c,BMI,waist circumference,abdominal fat thickness,TC,TG,and leptin of IGT patients were lower than those before treatment in both groups(P<0.05),and the treatment group was inferior to the control group(P<0.05,P<0.01). The level of adiponectin after treatment was higher than that before treatment in both groups(P<0.05),and the treatment group was superior to the control group(P<0.05).Conclusion: SQMWDH combined with acarbose is effective in treating IGT patients by effectively reducing 2 h OGTT and abdominal fat thickness to alleviate obesity and improve the constitution of patients.
作者
王家平
朱红霞
李英
WANG Jia-ping;ZHU Hong-xia;LI Ying(The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;Chengdu Shuangliu Hospital Traditional Chinese Medicine,Chengdu 610200,China;The First People's Hospital of Shuangliu District,Chengdu 610200,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第22期108-112,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
成都市医学科研项目(2017046)。
