摘要
目的观察电针联合塞来昔布和甲氨蝶呤治疗中老年类风湿关节炎(RA)的临床疗效。方法纳入中老年RA患者92例,随机分为对照组和观察组。对照组46例,予口服塞来昔布胶囊和甲氨蝶呤治疗;观察组46例,在对照组治疗基础上联合电针治疗。观察两组临床疗效,比较两组治疗前后关节功能评分、双手握力、晨僵、实验室指标[血沉(ESR)、C反应蛋白(CRP)和类风湿因子(RF)水平]的变化,比较两组不良反应发生情况。结果观察组总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组关节功能评分较治疗前均下降(P<0.05),双手握力较治疗前均升高(P<0.05),晨僵时间较治疗前缩短(P<0.05),实验室指标(ESR、CRP、RF)较治疗前下降(P<0.05);观察组治疗后上述结果均优于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论电针联合塞来昔布和甲氨蝶呤治疗中老年类风湿关节炎的临床疗效优于单纯药物治疗,能更有效地改善症状,且不良反应发生率更低。
Objective To observe the clinical efficacy of electroacupuncture plus Celecoxib and Methotrexate for rheumatoid arthritis(RA) in the elderly. Method Ninety-two elderly patients with RA were recruited and randomized into a control group and an observation group. Forty-six cases in the control group were given oral administration of Celecoxib capsules and Methotrexate;the other 46 cases in the observation group received electroacupuncture treatment in addition to the intervention in the control group. Clinical efficacy was observed in both groups. Joint function score,hand-grip strength, morning stiffness, and laboratory indexes [erythrocyte sedimentation rate(ESR), C-reactive protein(CRP) and rheumatoid factor(RF)] in the two groups were compared before and after treatment, as well as the adverse reactions. Result The total effective rate in the observation group than higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment, the joint function score dropped(P<0.05), hand-grip strength increased(P<0.05), morning stiffness duration was shorter(P<0.05), and the laboratory indexes(ESR, CRP and RF) declined(P<0.05) in both groups;the above outcome measures in the observation group were better than those in the control group(P<0.05). The adverse reaction rate was lower in the observation group than in the control group(P<0.05). Conclusion Electroacupuncture plus Celecoxib and Methotrexate can produce more significant efficacy in treating RA in the elderly than medication alone;it can more effectively improve the symptoms while causing fewer adverse reactions.
作者
林桂英
曾海财
LIN Gui-ying;ZENG Hai-cai(900th Hospital of PLA,Fuzhou 350003,China)
出处
《上海针灸杂志》
2021年第10期1223-1227,共5页
Shanghai Journal of Acupuncture and Moxibustion
关键词
针刺疗法
电针
针药并用
关节炎
类风湿
关节功能
塞来昔布
甲氨蝶呤
Acupuncture therapy
Electroacupuncture
Acupuncture medication combined
Arthritis,Rheumatoid
Joint function
Celecoxib
Methotrexate
