摘要
霉酚酸是世界上应用最广泛的免疫抑制剂之一,市场需求巨大。目前为止,主要是通过真菌发酵的方式进行霉酚酸的工业生产,而用于生产的菌株多是经过诱变的高产短密青霉菌。本文从霉酚酸的研究应用现状、化学合成以及生物合成途径、遗传调控、发酵生产以及市场分析等方面对霉酚酸的研究及产业化进展进行了系统综述。为该药物的新颖衍生物开发、提高产率以及应用先进生物技术智能化创制提供重要参考和依据。
Mycophenolic acid is one of the most widely used immunosuppressant in the world,and the market demand is huge.So far,the industrial production of mycophenolic acid is mainly through fungal fermentation,and the strains used for production are mostly mutagenized high-yielding Penicillium brevicompactum.This article systematically reviews the research and industrialization progress of mycophenolic acid.Five aspects including current research and application of mycophenolic acid,chemical synthesis and biosynthetic pathways,genetic regulation,fermentation production and market analysis are described.This review will provide valuable information for the development of novel derivatives of the drug,the improvement of yield,and the intelligent creation of advanced biotechnology in the future.
作者
黄润业
亓兰达
陈国参
尹文兵
Runye Huang;Landa Qi;Guocan Chen;Wenbing Yin(Henan Academy of Science Institute of Biology,Zhengzhou 450008,Henan Province,China;State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,China)
出处
《微生物学报》
CAS
CSCD
北大核心
2021年第10期3010-3025,共16页
Acta Microbiologica Sinica
基金
国家重点研发计划(2020YFA0907801)
国家自然科学基金(21807108)
河南省科学院省级特聘研究员项目(200505006)。
关键词
霉酚酸
生物合成
调控途径
发酵
mycophenolic acid
biosynthesis
regulatory pathway
fermentation
