摘要
目的进行维生素D联合门冬胰岛素对妊娠期糖尿病患者血清指标及分娩结局影响分析。方法选取医院2019年8月—2020年7月收治的妊娠期糖尿病患者86例,按照随机法分为两组,对照组43例患者采用门冬胰岛素治疗,观察组43例患者采用门冬胰岛素联合维生素D治疗。根据Toll样受体4(TLR4)、血管细胞黏附分子1(VCAM-1)对比两组治疗前后血清指标。根据空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)水平对比两组治疗前后血糖水平。根据巨大儿、呼吸窘迫、黄疸及早产儿发生率对比两组患者妊娠结局。结果治疗前两组患者TLR4、VCAM-1水平的差异无统计学意义(P>0.05),治疗后观察组TLR4、VCAM-1水平显著降低对照组,组间差异有统计学意义(P<0.05)。治疗前两组FPG、2 h PG及HbA1c等水平的差异无统计学意义(P>0.05),治疗后观察组FPG、2 h PG及HbA1c等水平均优于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局总发生率均低于对照组,组间差异有统计学意义(P<0.05)。结论采用维生素D联合门冬胰岛素对妊娠期糖尿病患者治疗,显著降低患者各项血清指标及血糖水平,改善患者妊娠结局。
Objective To analyze the effect of vitamin D combined with insulin aspart on serum index and delivery outcome in patients with gestational diabetes Mellitus(GDM).Methods From August 2019 to July 2020,86 GDM patients were selected,according to the method of randomization,43 patients in the control group were treated with insulin aspart and 43 patients in the observation group were treated with insulin aspart. Serum index of toll-like receptor 4 (TLR4) and vascular cell adhesion molecule 1(VCAM-1) were compared before and after treatment. Fasting blood glucose (FPG). Two hours postprandial blood glucose (2 h PG) and glycosylated hemoglobin (HbA1c) were compared before and after treatment. According to the incidence of macrosomia, respiratory distress, jaundice and prematurity, the pregnancy outcomes were compared between the two groups. Results Before treatment, there was no difference in TLR4 and VCAM-1 between the two groups (P > 0.05). After treatment, the levels of TLR4 and VCAM-1 in the observation group were significantly lower than those in the control group (P < 0.05). There was no difference in FPG, 2 h PG and HbA1c between the two groups before treatment (P > 0.05). After treatment, the levels of FPG, 2 h PG and HbA1c in the observation group were better than those in the control group (P < 0.05). The total incidence of adverse pregnancy outcomes the observation group was lower than that in the control group (P < 0.05). Conclusion The treatment of gestational diabetes mellitus with vitamin D combined with insulin aspart can significantly reduce serum and glucose levels and improve the outcome of pregnancy.
作者
李真
LI Zhen(Department of Obstetrics,Dalang Hospital of Dongguan,Dongguan Guangdong 523700,China)
出处
《中国卫生标准管理》
2021年第18期93-96,共4页
China Health Standard Management
关键词
妊娠期糖尿病
维生素D
门冬胰岛素
血清指标
血糖水平
妊娠结局
gestational diabetes mellitus
vitamin D
insulin aspart
serum index
blood sugar level
pregnancy outcome
