摘要
目的研究妊娠高血压疾病(HDP)中妊娠期高血压和子痫前期与早产儿发生的相关性。方法纳入2019年参与我院建立的优生优育队列研究的460名孕妇,在所有孕妇的孕早期收集基本资料,同时在其孕早、中和晚期进行HDP的诊断。基于对其孕周进行精准评估,将孕周为37~38^(+6)出生的新生儿为早产儿。进行多因素Logistic回归分析,对HDP中妊娠期高血压及子痫前期与早产儿发生的相关性进行分析。结果HDP发生率为8.8%(28例),妊娠期高血压和子痫前期组分别为6.0%(19例)和2.8%(9例)。妊娠期高血压组、子痫前期组与血压正常组比较,孕前BMI均较高(F=4.57,P<0.05)。初产产妇在妊娠期高血压组、子痫前期组和血压正常组中分别占89.5%、88.9%、96.9%,组间比较差异无统计学意义(P>0.05);男性新生儿分别占52.6%、44.4%、53.3%,组间比较差异无统计学意义(P>0.05);妊娠期高血压组和子痫前期组早期儿OR值(95%CI)分别为1.52(0.95,2.38)和4.58(2.12,9.59)。妊娠期高血压组与早期儿发生无相关性(P>0.05),子痫前期组与早产儿发生显著相关(P<0.05)。结论子痫前期增加了早期儿的发生,对孕妇的孕期采取有效干预措施可减少早产儿的发生。
Objective To investigate the correlation of gestational hypertension and preeclampsia with early term birth in hypertensive disorders of pregnancy(HDP).Methods Included were 460 pregnant women who participated our eugenics cohort study in 2019.The basic information in the first trimester were collected from all these women,and then during the three trimesters,the women were evaluated for diagnosis of HDP.Based on accurate assessment of gestational age,early term infants were defined as those born at gestational weeks 37-38^(+6).Multivariate logistic regression was performed to determine the correlation of gestational hypertension and preeclampsia in HDP and early term birth.Results HDP was found in 8.8%(n=28)of all women,with gestational hypertension found in 6.0%(n=19)and preeclampsia in 2.8%(n=9),respectively.Compared with normal women,those with gestational hypertension or preeclampsia had higher BMI before pregnancy(F=4.57,P<0.05).Of women with gestational hypertension,preeclampsia,and normal pregnant women,primiparae accounted for 89.5%,88.9%,and 96.9%,respectively(P>0.05);male newborns accounted for 52.6%,44.4%,and 53.3%,respectively,with no significant difference between groups(P>0.05).The OR(95%CI)of early term birth in women with gestational hypertension and preeclampsia were 1.52(0.95,2.38)and 4.58(2.12,9.59),respectively.Correlation between gestational hypertension and early term birth was not found(P>0.05),but rather,preeclampsia was significantly correlated with early term birth(P<0.05).Conclusion Preeclampsia increases the incidence of early term birth.Effective intervention measures for women during pregnancy may reduce the incidence of early term birth.
作者
笪慧佳
吴夕华
Da Huijia;Wu Xihua(Department of Obstetrics,Nanjing Hospital of Traditional Chinese Medicine,Jiangsu 210000,China)
出处
《中国药物与临床》
CAS
2021年第17期2926-2928,共3页
Chinese Remedies & Clinics
关键词
妊娠期高血压
子痫前期
早期儿
相关性
Gestational hypertension
Preeclampsia
Early term infants
Correlation
