摘要
该文综述了基于液相色谱-高分辨质谱联用(LC-HRMS)技术开展的沉积物和颗粒物中有机污染物分析的研究进展,包括LC-HRMS分析策略、分析流程及其在目标物、可疑物和非目标物分析中的实际应用,重点介绍了高通量分析、新兴污染物筛查、不同数据库的特点及应用、未知化合物鉴定置信水平、数据非依赖性采集和优先级策略等内容,初步探讨了该技术目前存在的问题并对其发展和应用进行了展望,以期进一步提高识别和鉴定工作的效率,更好地开展环境样品中有机污染物的筛查和监测研究。文中涉及的高分辨质谱的相关通用性内容,也为该技术在其他领域的应用提供了一定的参考和启发。
Sediments and particulate matters in aquatic environment take the roles of main carriers and final destinations of hydrophobic and lipophilic organic contaminants,which have been proved to be potential secondary pollution sources for releasing contaminants to aquatic environment again.Organic pollution in sediments and particulate matters is an important factor affecting the safety of aquatic environment.Therefore,it is essential to expand the screening scope of organic contaminants as wide as possible to understand and grasp the comprehensive pollution situation.Liquid chromatography-high resolution mass spectrometry(LC-HRMS)is suitable for the analysis of a wide range of organic pollutants from medium to strong polarity.Its application could not only realize the high-throughput analysis,but also expand the identification of unknowns.The researches on organic contaminants in sediments and particulate matters by LC-HRMS are reviewed in this paper,including the analysis strategies,the analysis process and the practical analysis on target,suspect and nontarget organic compounds,and the high-throughput analysis,screening of emerging contaminants,characteristics and applications of different databases,compound identification confidence level,data independence acquisition and prioritization strategies are focused.Meanwhile,the existing problems and prospects of LC-HRMS applications are summarized and addressed,so as to improve the identification efficiency and better carry out the screening and monitoring of organic contaminants in environmental samples.Furthermore,the relevant general content of HRMS involved in this article also provides a certain reference and inspiration for the applications of this technique in other fields.
作者
赵亚静
邹立
牛增元
罗忻
李晓瞳
ZHAO Ya-jing;ZOU Li;NIU Zeng-yuan;LUO Xin;LI Xiao-tong(Key Laboratory of Marine Environment and Ecology,Ministry of Education,Ocean University of China,Qingdao 266100,China;Qingdao Customs Technology Center,Qingdao 266002,China)
出处
《分析测试学报》
CAS
CSCD
北大核心
2021年第9期1396-1408,共13页
Journal of Instrumental Analysis
基金
国家重点研发计划项目(2016YFF0203702)
国家自然科学基金重点项目(41831280)。
关键词
沉积物
颗粒物
有机污染物
液相色谱
高分辨质谱
筛查
sediments
particulate matters
organic contaminants
liquid chromatography
high resolution mass spectrometry
screening
