摘要
目的分析艾滋病(AIDS)合并隐球菌感染患者的生化指标,有助于合并症AIDS病例的确认。方法对2019年1月—2020年5月连云港市第一人民医院收治的33例单纯AIDS患者(AIDS组)及38例AIDS合并隐球菌感染患者(合并感染组)的临床资料进行回顾性分析,对比两组患者脑脊液和血液生化指标水平。结果合并感染组患者的脑脊液蛋白质(CSF-Pro)、脑脊液压力、脑脊液总细胞、脑脊液白细胞(WBC),血红细胞(RBC)、血红蛋白(HGB)、谷丙转氨酶(ALT)、脑脊液人类免疫缺陷病毒(HIV)RNA、血小板(PLT)、血清白蛋白(ALB)分别为(57.09±5.57)g/L、(265.17±30.24)mmH2O、(51.24±7.23)细胞/μl、(11.23±1.74)细胞/μl、(3.81±0.53)×10^(12)/L、(117.98±13.21)g/L、(29.23±5.02)U/L、(523.01±39.54)拷贝/ml、(179.69±13.04)×10^(9)/L、(37.98±5.67)g/L,高于AIDS组,差异均有统计学意义(P<0.05)。合并感染组患者的脑脊液葡萄糖(CSF-Glu)、脑脊液氯化物(CSF-Cl)、CD3+、CD4+、CD8+、血沉(ESR)、血氯、乳酸脱氢酶(LDH)、C-反应蛋白(CRP)水平分别为(2.29±0.38)mmol/L、(116.58±12.97)mmol/L、(452.99±50.26)细胞/μl、(52.34±6.11)细胞/μl、(435.89±40.17)细胞/μl、(28.69±3.95)mm/h、(97.13±10.39)mmol/L、(179.86±22.54)U/L、(14.95±2.01)mg/L,低于AIDS组,差异均有统计学意义(P<0.05)。结论和单纯AIDS患者相比,AIDS合并隐球菌感染患者的CSF-Pro、脑脊液压力等指标较高,CSF-Glu、CSF-Cl、CD4+、ESR等指标较低。
Objective To analyze the biochemical parameters in cases of acquired immunodeficiency syndrome(AIDS) with cryptococcal infection(CI),and to help confirm AIDS with comorbidities. Methods A retrospective analysis was performed on the clinical data of 33 AIDS cases(AIDS group) and 38 AIDS with CI patients(AIDS with CI group) who were admitted to Lianyungang First People’s Hospital from January 2019 to May 2020. The two groups were compared in terms of the biochemical parameters of cerebrospinal fluid and blood. Results The AIDS with CI group had significantly higher cerebrospinal fluid protein(CSF-Pro) level(57.09±5.57 g/L),cerebrospinal fluid pressure(265.17 ±30.24 mmH2 O),total cerebrospinal fluid cell count(51.24 ±7.23 cells/μl),cerebrospinal fluid white blood cell count(11.23±1.74 cells/μl),red blood cell count [(3.81±0.53)×10^(12)/L],hemoglobin count(117.98±13.21 g/L),alanine aminotransferase level(29.23 ±5.02 U/L),cerebrospinal fluid human immunodeficiency virus RNA level(523.01 ±39.54 copies/ml),platelet count [(179.69 ±13.04) ×10^(9)/L],and serum albumin level(37.98 ±5.67 g/L),and significantly lower cerebrospinal fluid glucose(CSF-Glu) level(2.29±0.38 mmol/L),cerebrospinal fluid chloride(CSFCl) level(116.58±12.97 mmol/L),CD3+(452.99±50.26 cells/μL),CD4+(52.34±6.11 cells/μl),CD8 +(435.89±40.17 cells/μl),erythrocyte sedimentation rate(ESR,28.69±3.95 mm/h),blood chloride level(97.13±10.39 mmol/L),lactate dehydrogenase level(179.86±22.54 U/L),C-reactive protein level(14.95±2.01 mg/L) than the AIDS group(P<0.05).Conclusion Compared with the patients with AIDS,AIDS patients with CI had higher levels of parameters such as CSF-Pro and cerebrospinal fluid pressure,and lower levels of parameters such as CSF-Glu,CSF-Cl,CD4+ and ESR.
作者
骞田
张田
QIAN Tian;ZHANG Tian(Department of Blood Transfusion,Lianyungang First People’s Hospital,Lianyungang,Jiangsu 222000,China;不详)
出处
《中国国境卫生检疫杂志》
CAS
2021年第4期298-300,共3页
Chinese Journal of Frontier Health and Quarantine
关键词
艾滋病
隐球菌
脑脊液
生化指标
Acquired immunodeficiency syndrome
Cryptococcal
Cerebrospinal fluid
Biochemical indicators
