摘要
目的探讨古代医家应用雄黄治疮杀毒的药物配伍与用药规律。方法参考《中国中医古籍总目》查阅古代医家经典古籍中含有雄黄的方剂,在建立方剂数据库的基础上,首先对药物使用频次、四气五味、性味归经等进行统计分析,其次对药物进行关联规则和可视化网络图分析,全面展示药物之间的联系,最后对药物进行聚类分析,研究药物临床使用的分类。结果纳入研究的含有雄黄方剂共459首,涉及药物480种,累计用药次数达2980次。药物累计使用频率≥80%的药物共有32味。在雄黄处方中,朱砂、麝香、附子、白矾、巴豆、牛黄等是高频药物,使用频次在60次以上,性味以温、寒并用,辛、甘(淡)为主,药物归经以肝、脾、心经为主。通过关联规则及可视化网络图分析显示,支持度最高的药物组合为雄黄-朱砂,其次为雄黄-麝香。聚类分析结果显示,高频药物可聚为5类。结论基于数据挖掘方法可以系统地分析出古代医家使用雄黄治疗疮痈肿毒的用药规律,从而为现代临床安全使用雄黄提供参考依据。
Objective To explore the drug compatibility and relevant medication rules in applications of Realgar in the treatment of sores and poison in ancient doctors.Methods Realgar prescriptions recorded in classic ancient books of Chinese ancient doctors were searched based on the"General Catalogue of Ancient Books on Chinese Medicine",so as to establish a relevant prescription database,and then,a statistical analysis on the frequency of drug use,four characters,five tastes,nature,flavor and channel tropism was conducted based on the database.Subsequently,the drug association rules and visual network diagrams were analyzed,so as to demonstrate the connections between drugs comprehensively.Finally,a cluster analysis was conducted to explore the classification of drugs for clinical use.Results A total of 459 prescriptions containing Realgar were included in the study,involving 480 kinds of drugs,and the accumulative times of medication reached 2980.There were 32 drugs with accumulative frequency≥80%.In the prescriptions concerning Realgar,Cinnabar,Musk,Radix Aconite Lateralis Preparata,Alum,Croton and Bezoar were used for more than 60 times as high frequency drugs.For the nature and flavor,both warm and cold drugs were used,with pungent and sweet(light)flavors as the main.For channel tropism,liver,spleen,and heart meridians were dominant.The analysis on the drug association rules and visual network diagrams showed that the drug combination with the highest support was Realgar-Cinnabar,followed by Realgar-Musk.The cluster analysis results showed that high frequency drugs could be grouped into 5 categories.Conclusion A systematic analysis on the Realgar medication rules of ancient doctors for treating ulcer and carbuncle may be performed based on a data mining method,so as provide references for safe application of Realgar in modern clinical practice.
作者
黄莹
杨俊玲
肖凯月
HUANG Ying;YANG Jun-ling;XIAO Kai-yue(Department of Pharmacy,Urumqi Traditional Chinese Medicine Hospital,Xinjiang Uygur Autonomous Region,Urumqi 830000,China)
出处
《中国当代医药》
CAS
2021年第24期4-7,11,共5页
China Modern Medicine
基金
新疆维吾尔自治区乌鲁木齐市中医医院科学技术计划项目(Y201823)。
关键词
数据挖掘
雄黄
治疮杀毒
古代医家用药规律
Data mining
Realgar
Treatment of sores and poison
Medication rules of ancient doctors
