摘要
目的探讨术后血清细胞角蛋白19片段(CYFRA21-1)、胸苷激酶1(TK1)表达与膀胱尿路上皮癌(BUC)患者生存预后的关系。方法选取2013年1月~2015年1月屯昌县人民医院85例BUC患者,检测患者术后血清CYFRA21-1、TK1水平,分析不同临床特征患者血清CYFRA21-1、TK1表达的差异,探讨血清CYFRA21-1、TK1表达与BUC患者生存预后的关系。结果经治疗后,BUC患者血清CYFRA21-1、TK1表达量和阳性率比治疗前均明显降低,差异有统计学意义(P<0.05)。不同肿瘤数目、分期、分级和不同预后患者术后血清CYFRA21-1、TK1表达阳性率比较,差异有统计学意义(P<0.05);多发病灶、肿瘤T2-T3分期、高级别和血清CYFRA21-1、TK1阳性表达是影响BUC患者独立危险因素,差异有统计学意义(P<0.05);Log-Rank分析显示,血清CYFRA21-1、TK1阳性表达患者5年生存率显著低于阴性表达患者,差异有统计学意义(P<0.05)。结论术后CYFRA21-1、TK1的表达与BUC患者病情密切相关,可作为预测患者不良预后的独立危险因子。
Objective To investigate the expression of CYFRA21-1,thymidine kinase 1(TK1)in patients with bladder urothelial carcinoma(BUC)after surgery and its relationship with prognosis.Methods 85 patients with BUC were collected for this study.The levels of serum CYFRA21-1 and TK1 were detected.The differences of serum CYFRA21-1 and TK1 expression in patients with different clinical characteristics were analyzed.The relationships between expression of CYFRA21-1,TK1 and the prognosis of BUC patients were investigated.Results After treatment,the levels and positive rates of serum CYFRA21-1 and TK1 in BUC patients were significantly reduced(P<0.05).The positive rates of serum CYFRA21-1 and TK1 were statistically significant in patients with different tumor number,stage,grade and prognosis(P<0.05).Multiple lesions,tumor t2-t3 stage,high grade and positive expression of serum CYFRA21-1 and TK1 were independent risk factors for BUC patients(P<0.05).Log-rank analysis showed that the 5-year survival rate of patients with serum CYFRA21-1 and positive TK1 expression was significantly lower than patients with negative expression(P<0.05).Conclusion The expression of CYFRA21-1 and TK1 is closely related to condition of BUC,which can be used as independent risk factors for predicting poor prognosis of patients.
作者
陈楚君
王宁
王丽娜
沈光辉
Chen Chujun;Wang Ning;Wang Lina(Tunchang People's Hospital,Hainan Tunchang 571600,China)
出处
《中华保健医学杂志》
2021年第4期349-351,共3页
Chinese Journal of Health Care and Medicine
基金
海南省卫生计生行业科研项目(18A200064)。
