摘要
目的:探讨谷氨酰胺联合美沙拉嗪保留灌肠治疗子宫颈癌放疗所致的急性放射性肠炎的临床效果。方法:回顾性分析2015年1月-2020年12月住院治疗的65例子宫颈癌放疗患者的临床资料,65例患者按照治疗方法的不同,分为对照组(美沙拉嗪保留灌肠治疗,n=31)和观察组(谷氨酰胺联合美沙拉嗪保留灌肠治疗,n=34)。比较两组患者临床疗效、生命质量、炎症因子水平、不良反应发生率。结果:观察组临床疗效总有效率明显高于对照组(P<0.05)。治疗后,两组日常生活、社会活动、抑郁心理、焦虑心理评分明显低于治疗前,观察组明显低于对照组(P<0.05)。治疗后,两组IL-1、IL-6、TNF-α水平明显低于治疗前,且观察组明显低于对照组(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:采用谷氨酰胺联合美沙拉嗪保留灌肠的治疗方法,有利于减轻子宫颈癌放疗引起的急性放射性肠炎患者肠道炎症反应,改善患者临床症状及生命质量,提高临床疗效,效果安全可靠。
Objective:To investigate the clinical efficacy of Glutamine combined with Mesalazine retention enema in the treatment of acute radiation enteritis caused by radiotherapy for cervical cancer.Method:The clinical data of 65 patients with cervical cancer treated by radiotherapy from January 2015 to December 2020 were retrospectively analyzed.According to different treatment methods,65 patients were divided into the control group (Mesalazine retention enema,n=31) and the observation group (Glutamine combined with Mesalazine retention enema,n=34).The clinical efficacy,quality of life,levels of inflammatory factors and incidence of adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).After treatment,the scores of daily life,social activities,depression and anxiety in the two groups were significantly lower than those before treatment,and those in the observation group were significantly lower than those in the control group (P<0.05).After treatment,the levels of IL-1,IL-6 and TNF-α in the two groups were significantly lower than before treatment,and the observation group was significantly lower than the control group (P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion:Glutamine combined with Mesalazine retention enema can reduce the intestinal inflammatory reaction in patients with acute radiation enteritis caused by radiotherapy of cervical cancer,improve the clinical symptoms and quality of life of patients,improve the clinical efficacy,and the effect is safe and reliable.
作者
詹增钦
李贞伦
刘颖
李景涛
时桢
ZHAN Zengqin;LI Zhenlun;LIU Ying;LI Jingtao;SHI Zhen(Jinshazhou Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510000,China)
出处
《中外医学研究》
2021年第22期69-71,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
谷氨酰胺
美沙拉嗪
子宫颈癌
放疗
急性放射性肠炎
Glutamine
Mesalazine
Cervical cancer
Radiotherapy
Acute radiation enteritis
