摘要
目的研究野葛Pueraria lobata根茎的化学成分。方法运用HP-20大孔吸附树脂、硅胶、ODS和Sephadex LH-20等柱色谱以及反相制备型HPLC等各种现代色谱分离技术进行系统的分离纯化,根据化合物的光谱数据和理化性质进行结构鉴定。结果从野葛根茎的甲醇提取物中分离得到11个化合物,分别鉴定为葛檀素(1)、芒柄花苷(2)、大豆苷(3)、大豆素(4)、4′,8-dimethoxy-7-O-β-D-glucopyranosylisoflavone(5)、异芒柄花苷(6)、染料木素(7)、formononetin-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside(8)、7,2′,4′-trihydroxyisoflavone(9)、3′-methoxydaidzein(10)和芒柄花素(11)。结论化合物1为1个新的6a,11a-脱氢紫檀素,化合物8和9为首次从葛属植物中分离得到。
Objective To isolate and characterize the chemical constituents from the rhizomes of Pueraria lobata.Methods The compounds were isolated and purified by various modern chromatographic techniques,and their structures were identified by spectroscopic data and physicochemical properties.Results Eleven compounds were isolated from the Me OH extract of the rhizomes of P.lobata,which were elucidated as pueracarpanin(1),ononin(2),daidzin(3),daidzein(4),4′,8-dimethoxy-7-O-β-Dglucopyranosyl-isoflavone(5),isoononin(6),genistein(7),formononetin-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside(8),7,2′,4′-trihydroxyisoflavone(9),3′-methoxydaidzein(10)and formononetin(11).Conclusion Compound 1 is a new 6 a,11 a-dehydropterocarpin,and compounds 8 and 9 are isolated from the genus Pueraria for the first time.
作者
杜锟
田梦茹
盛丹阳
袁明昊
王琰琰
李梦园
支燕乐
马金莲
薛贵民
陈辉
孙彦君
冯卫生
DU Kun;TIAN Meng-ru;SHENG Dan-yang;YUAN Ming-hao;WANG Yan-yan;LI Meng-yuan;ZHI Yan-le;MA Jin-lian;XUE Gui-min;CHEN hui;SUN Yan-jun;FENG Wei-sheng(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center for Respiratory Disease Diagnosis,Treatment&Chinese Medicine Development of Henan Province,Henan University of Chinese Medicine,Zhengzhou 450046,China;Academy of Chinese medical Sciences,Henan University of Chinese Medicine,Zhengzhou,450046,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第14期4130-4135,共6页
Chinese Traditional and Herbal Drugs
基金
河南省科技攻关项目(182102310288)
河南中医药大学博士科研基金(BSJJ2018-19)
河南省高等学校重点科研项目(21A360002)
河南省大学生创新项目(S201910471010)。
关键词
葛根
6a
11a-脱氢紫檀素
异黄酮苷
染料木素
芒柄花素
葛檀素
Pueraria lobate(Willd.)Ohwi
6a
11a-dehydropterocarpan
isoflavonoid glycoside
genistein
formononetin
pueracarpanin
