摘要
目的探讨氨磺必利联合阿立哌唑对精神分裂症患者临床疗效、糖脂代谢及心肌功能的影响。方法将116例精神分裂症患者按随机数字表法分为两组,各58例。对照组采用氨磺必利治疗,观察组采用氨磺必利联合阿立哌唑治疗,观察8周。比较两组的临床疗效及治疗前后阳性与阴性症状量表、简易智能状态检查量表评分,心肌功能、糖脂代谢以及血清垂体泌乳素水平。结果观察组总有效率显著高于对照组(P<0.05)。治疗后两组阳性与阴性症状量表评分较治疗前显著降低(P<0.01),观察组显著低于对照组(P<0.01)。治疗后两组简易智能状态检查量表评分较治疗前显著升高(P<0.01),观察组显著高于对照组(P<0.01)。治疗后两组血清乳酸盐脱氢酶、天门冬氨酸氨基转移酶、肌酸激酶同工酶及高密度脂蛋白水平较治疗前显著升高(P<0.01),血清垂体泌乳素较治疗前显著降低(P<0.01),组间比较差异无统计学意义(P>0.05);两组空腹血糖水平较治疗前显著降低(P<0.01),观察组显著低于对照组(P<0.01)。结论氨磺必利联合阿立哌唑治疗精神分裂症疗效显著,能促进糖代谢,改善患者认知功能,对脂代谢、心肌功能和血清垂体泌乳素水平无进一步影响。
Objective To analyze the effects of amisulpride combined with aripiprazole on the clinical efficacy,glucolipid metabolism and myocardial function in patients with schizophrenia.Methods A total of 116 patients with schizophrenia were randomly divided into two groups,58 cases in each group.The control group was treated with amisulpride,and the observation group was treated with amisulpride combined with aripiprazole for 8 weeks.The clinical efficacy of the two groups were compared,the scores of the positive and negative syndrome scale(PANSS),mini-mental state examination(MMSE),myocardial function,glucose and lipid metabolism,and serum pituitary prolactin(PRL)levels were compared before and after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the PANSS scores of the two groups were significantly lower than those before treatment(P<0.01),and the observation group was significantly lower than the control group(P<0.01).The MMSE scores of the two groups were significantly higher than those before treatment(P<0.01),and the observation group was significantly higher than the control group(P<0.01).After treatment,the levels of serum lactate dehydrogenase(LDH),aspartate amino transferase(AST),creatine kinase-MB(CK-MB)and high-density lipoprotein(HDL)in the two groups were significantly higher than those before treatment(P<0.01),and serum pituitary prolactin(PRL)was significantly lower than that before treatment(P<0.01).There was no significant difference between the two groups(P>0.05).The fasting blood glucose(FBG)levels of the two groups were significantly lower than those before treatment(P<0.01),and the observation group was significantly lower than the control group(P<0.01).Conclusions Amisulpride combined with aripiprazole has a significant effect in the treatment of schizophrenia.It can promote glucose metabolism and improve the cognitive function of patients.It has no further effect on lipid metabolism,myocardial function and serum PRL level.
作者
孙健
唐彩霞
孙梅玲
Sun Jian;Tang Caixia;Sun Meiling(Zhumadian Psychiatric Hospital,Zhumadian 463000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2021年第4期16-19,共4页
Journal of Clinical Psychosomatic Diseases
