摘要
Precise,quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skinbased pathologies,and regulating external appearance.Here we introduce multimodal sensors with important capabilities in this context,rendered in soft,ultrathin,‘skin-like’formats with numerous advantages over alternative technologies,including the ability to establish intimate,conformal contact without applied pressure,and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the skin.Systematic in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature,thermal conductivity,thermal diffusivity,volumetric heat capacity,and electrical impedance using simple analysis algorithms.Clinical studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.
基金
YM and XF acknowledge the support from the National Basic Research Program of China(Grant No.2015CB351900)
National Natural Science Foundation of China(Grant Nos.11402135,11320101001)
YH acknowledges the support from NSF(Grant Nos.DMR1121262,CMMI1300846,CMMI1400169,and CMMI1534120)
the NIH(Grant No.R01EB019337)
RCW acknowledges support from the National Science Foundation under grant no.DGE-1144245.
