摘要
目的观察曲骨关元针刺、艾盒灸联合盐酸坦索罗辛缓释胶囊治疗良性前列腺增生(BPH)的临床疗效。方法将96例BPH患者随机分为观察组和对照组,各48例,对照组给予盐酸坦索罗辛缓释胶囊治疗,观察组在此基础上给予曲骨关元针刺、艾盒灸治疗,均治疗3个月,观察两组治疗前后国际前列腺症状评分(IPSS)、前列腺体积(TPV)、残余尿量、国际勃起功能指数-5问卷(IIEF-5)评分、美国国立卫生研究所制定的慢性前列腺炎症状指数(NIH-CPSI)、性激素、前列腺特异性抗原(PSA)及血流变指标的变化。结果两组患者治疗后IPSS评分及TPV、残余尿量均显著降低,IIEF-5评分均显著升高,且观察组各指标改善幅度大于对照组,差异有统计学意义(P<0.05);两组患者治疗后NIH-CPSI评分均显著降低,且观察组NIH-CPSI评分低于对照组,差异有统计学意义(P<0.05);两组患者治疗后雌二醇、睾酮、睾酮/雌二醇均显著升高,PSA水平均显著降低,观察组改善幅度大于对照组,差异有统计学意义(P<0.05);两组患者治疗后全血高切黏度、全血低切黏度、聚集指数、刚性指数、纤维蛋白原水平均显著降低,且观察组血流变指标均低于对照组,差异有统计学意义(P<0.05)。结论曲骨关元针刺、艾盒灸联合盐酸坦索罗辛缓释胶囊治疗BPH疗效确切,能有效减轻患者前列腺症状,提高性激素水平,改善性功能和血流变指标。
Objective To observe the clinical efficacy of acupuncture and moxa box moxibustion at Qugu(RN2)and Guanyuan(RN4)combined with Tamsulosin Hydrochloride Sustained-Release Capsule in the treatment of benign prostatic hyperplasia(BPH).Methods Ninety-six patients with BPH were randomly divided into observation group and control group,with 48 cases in each group.The control group was treated with Tamsulosin Hydrochloride Sustained-Release Capsule and the observation group was additionally given acupuncture and moxa box moxibustion at Qugu(RN2)and Guanyuan(RN4).All patients were treated for 3 months.The international prostate symptom score(IPSS),prostate volume(TPV),residual urine volume,international index of erectile function-5 questionnaire(IIEF-5)score,national institutes of health's chronic prostatitis symptoms index(NIH-CPSI),sex hormones,prostate specific antigen(PSA)and hemorheological parameters were observed in the two groups before and after treatment.Results The IPSS score,TPV and residual urine volume in the two groups were significantly decreased after treatment while the IIEF-5 score was significantly increased,and the improvement of each index in the observation group was greater than that in the control group(P<0.05).The NIH-CPSI score in the two group was significantly decreased after treatment,and the NIH-CPSI score in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of estradiol,testosterone and testosterone/estradiol in the two groups were significantly increased after treatment while the PSA level was significantly decreased,and the improvements in the observation group were greater than those in the control group(P<0.05).The whole blood high-shear viscosity,whole blood low-shear viscosity,aggregation index,rigidity index and fibrinogen level after treatment were significantly decreased in the two groups,and the hemorheological parameters in the observation group were lower than those in the control group(P<0.05).Conclusion Acupuncture and moxa box moxibustion at Qugu(RN2)and Guanyuan(RN4)combined with Tamsulosin Hydrochloride Sustained Release Capsule have exact efficacy in the treatment of BPH,which can effectively alleviate prostate symptoms,enhance sex hormones levels and improve sexual function and hemorheological parameters.
作者
应海芬
应海舟
王力
YING Haifen;YING Haizhou;WANG Li(Zhoushan Traditional Chinese Medicine Hospital,Zhoushan 316000,Zhejiang,China)
出处
《辽宁中医杂志》
CAS
2021年第4期173-176,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
浙江省中医药科技计划舟山专项(2014ZSZX08)。
关键词
曲骨
关元
针刺
艾盒灸
盐酸坦索罗辛
良性前列腺增生
Qugu(RN2)
Guanyuan(RN4)
acupuncture
moxa box moxibustion
tamsulosin hydrochloride
benign prostatic hyperplasia
