摘要
目的分析孕早期孕妇甲状腺激素水平异常现状并探讨其影响因素,为防治妊娠期甲状腺疾病提供参考资料。方法以山东大学某医院产科2020年2月至2021年1月孕1012周孕妇作为研究对象,检测该人群甲状腺激素水平并收集孕妇相关资料,采用描述流行病学分析方法对孕早期孕妇甲状腺激素水平异常情况进行分析,并采用单、多因素分析方法对甲状腺激素水平异常的影响因素进行分析。结果本研究共纳入孕早期孕妇3 754人,年龄2042岁,2035岁占77.1%,孕11<12周占41.6%,有甲状腺疾病家族史者占4.7%,有甲状腺疾病史者占2.9%。甲状腺激素水平异常179例,异常率为4.8%,以甲状腺功能减退(87例,占48.6%)及亚临床甲状腺功能减退(38例,占21.2%)多见。多因素Logistic回归分析结果显示焦虑(OR=2.026)、抑郁(OR=2.724)、有甲状腺疾病家族史(OR=3.438)、有甲状腺疾病史(OR=4.043)、血压异常(OR=1.931)、血脂异常(OR=1.539)、血糖异常(OR=1.446)的孕妇孕早期甲状腺激素水平异常可能性较高,食用盐类型为碘盐(OR=0.751)的孕妇孕早期甲状腺激素水平异常的可能性较小。结论孕早期孕妇甲状腺激素水平异常率较高,以甲状腺功能减退、亚临床甲状腺功能减退为主,其受到孕妇焦虑、抑郁、甲状腺疾病家族史、甲状腺疾病史、血压、血脂、血糖、食用盐等多因素影响,应加强对孕妇甲状腺疾病的筛查、监测和干预,保证母婴安全。
ObjectiveTo analyze the abnormal thyroid hormone levels in early pregnant women and its influencing factors,so as to provide reference for the prevention and treatment of thyroid disease during pregnancy.Methods Taking the pregnant women of 10-12 weeks gestation from February 2020 to January 2021 in the obstetrics department of a hospital in Jinan as the research object,the thyroid hormone levels of the population were detected and the relevant data were collected. Descriptive epidemiological analysis method was used to analyze the abnormal thyroid hormone levels of early pregnant women,and univariate and multivariate analysis methods were used to analyze its influencing factors.ResultsA total of 3 754 early pregnant women were enrolled,aged 20-42 years,77.1% were 20-35 years old,41.6% were11-11+6 weeks gestation,4.7% had a family history of thyroid disease,and those with a history of thyroid disease accounted for 2.9%. There were 179 cases of abnormal level of thyroid hormone,the abnormal rate was 4.8%,and hypothyroidism(87 cases,accounting for 48.6%)and subclinical hypothyroidism(38 cases,accounting for 21.2%)were more common.Multivariate Logistic regression analysis showed that pregnant women with anxiety(OR=2.026),depression(OR=2.724),a family history of thyroid disease(OR=3.438),a history of thyroid disease(OR=4.043),abnormal blood pressure(OR=1.931),dyslipidemia(OR=1.539),and abnormal blood glucose(OR=1.446)were more likely to have abnormal thyroid hormone levels in the early pregnancy,while pregnant women who consume iodized salt(OR=0.751)were less likely to have abnormal thyroid hormone levels in the early pregnancy.ConclusionThe abnormal rate of thyroid hormone levels in early pregnant women is high,mainly hypothyroidism and subclinical hypothyroidism,which are affected by pregnant women’s anxiety,depression,family history of thyroid disease,history of thyroid disease,blood pressure,blood lipids,blood glucose,salt consumption,etc. The screening,monitoring and intervention of thyroid disease in pregnant women should be strengthened to ensure the safety of mothers and babies.
作者
徐永涛
范刚
徐苗苗
XU Yong-tao;FAN Gang;XU Miao-miao(Shandong Provincial Hospitaly Shandong Universityy Jinan 250021,China;Maternal and Child Health Care Hospital of Shandong Province,Shandong University;Qilu Children's Hospital of Shandong University)
出处
《华南预防医学》
2021年第6期706-709,共4页
South China Journal of Preventive Medicine
关键词
孕早期
孕妇
甲状腺激素
甲状腺过氧化物酶抗体
游离甲状腺素
促甲状腺激素
Early pregnancy
Pregnant women
Thyroid hormone
Thyroid peroxidase antibody
Free thy-roxine
Thyroid-stimulating hormone
