摘要
目的分析在麻痹性内斜视治疗中应用A型肉毒毒素治疗的临床效果。方法于2017年12月—2020年6月方便择取40例麻痹性内斜视患者,按照治疗方法予以分组研究,20例患者实施A型肉毒毒素眼内肌注射治疗纳入注射组,20例实施A型肉毒毒素眼内肌注射治疗联合手术治疗纳入手术组,对照分析两组临床效果。结果注射治疗前,注射组斜视度数均值(+60.1±38.6)°,手术组斜视度数均值(+91.8±37.5)°;术前注射组斜视度数均值(+40.8±29.5)°,手术组斜视度数均值(+37.6±34.8)°;术后注射组斜视度数均值(+2.2±10.8)°,手术组斜视度数均值(+3.5±24.2)°;注射组矫正斜视度数均值(42.8±32.3)°,手术组矫正斜视度数均值(90.1±40.2)°,两组注射治疗前、术前及术后对比差异有统计学意义(t_(注射治疗前-术前)=1.777、4.738,P_(注射治疗前-术前)<0.05;t_(术前-术后)=5.495、3.598,P_(术前-术后)<0.05),术前、术后组间对比差异无统计学意义(t_(术前)=0.314,P_(术前)=0.378,t_(术后)=0.219,P_(术后)=0.414)。结论对于麻痹性内斜视患者来说,A型肉毒毒素眼内肌注射治疗可以避免内直肌挛缩,同时对外直肌肌力恢复有促进作用,可以辅助手术治疗,为手术奠定治疗基础,提高临床效果。
Objective To analyze the clinical effect of botulinum toxin type A in the treatment of paralytic esotropia.Methods From December 2017 to June 2020,40 patients with paralytic esotropia were conveniently selected and studied in groups according to the treatment method.20 patients received botulinum toxin type A intraocular muscle injection and were included in the injection group,20 cases of type A botulinum toxin intraocular muscle injection combined with surgical treatment were included in the operation group,and the clinical effects of the two groups were compared.Results Before injection treatment,the mean strabismus degree of the injection group(+60.1±38.6)°,the mean strabismus degree of the operation group(+91.8±37.5)°;the mean strabismus degree of the preoperative injection group(+40.8±29.5)°,the operation group strabismus mean value(+37.6±34.8)°;mean strabismus power in the postoperative injection group(+2.2±10.8)°,mean strabismus power in the operation group(+3.5±24.2)°;mean corrected strabismus power in the injection group(42.8±32.3)°,the mean correction of strabismus in the surgical group was(90.1±40.2)°,and there were statistically significant differences between the two groups before,and after injection treatment(t_(before injection-before operation)=1.777,4.738,P_(before injection-before operation)<0.05;t_(preoperative-postoperative)=5.495,3.598,P_(preoperative-postoperative)<0.05),there was no statistically significant difference between the preoperative and post operative groups(t_(preoperative)=0.314,P_(preoperative)=0.378,t_(postoperative)=0.219,P_(postoperative)=0.414).Conclusion For paralytic patients with esotropia,intraocular muscle injection of botulinum toxin type A can avoid medial rectus contracture and promote the recovery of external rectus muscle strength.At the same time,it can assist surgical treatment,lay the foundation for surgery and improve clinical results.
作者
姚立平
罗建
YAO Liping;LUO Jian(Inpatient Department,Dongguan Huaxia Eye Hospital,Dongguan,Guangdong Province,523000 China)
出处
《中外医疗》
2021年第15期45-47,共3页
China & Foreign Medical Treatment
关键词
A型肉毒毒素
麻痹性内斜视
临床效果
Botulinum toxin type A
Paralytic esotropia
Clinical effects
