摘要
目的探究对子宫腺肌症患者应用亮丙瑞林联合曼月乐的效果。方法选取2018年4月—2020年3月洪泽区人民医院妇产科接收子宫腺肌症患者78例,随机分为对照组和观察组,每组39例。对照组使用亮丙瑞林治疗,观察组于对照组基础上联合应用曼月乐节育环治疗,对比两组治疗效果及不良反应发生状况,并评估患者月经量变化和痛经状况。结果治疗前,两组患者月经失血图(PBAC)、口述评分法(VRS)评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者PBAC(40.1±6.1)分、VRS为(1.2±0.2)分,显著低于对照组的PBAC为(54.9±5.9)分、VRS(1.9±0.1)分,差异有统计学意义(P<0.05);观察组治疗总有效率为94.9%,高于对照组61.5%,差异有统计学意义(χ^(2)=12.712,P<0.05);观察组不良反应发生率为7.7%,明显低于对照组的28.2%,差异有统计学意义(χ^(2)=5.571,P<0.05)。结论对子宫腺肌症患者应用亮丙瑞林联合曼月乐治疗可取得理想效果,能够明显改善患者经期情况,减少不良反应的发生,值得被大力推广以及应用。
Objective To explore the effect of leuprolide combined with Mirena in patients with adenomyosis.Methods From April 2018 to March 2020,78 patients with adenomyosis were admitted to the department of obstetrics and gynecology of the People’s Hospital of Hongze District.They were randomly divided into a control group and an observation group,with 39 cases in each group.The control group was treated with leuprolide.The observation group was combined with Mirena on the basis of the control group.The treatment effects and adverse reactions were compared between the two groups,and the changes in menstrual volume and dysmenorrhea were evaluated.Results Before treatment,there was no significant difference in PBAC and VRS scores between the two groups of patients(P>0.05);after treatment,the observation group’s PBAC was(40.1±6.1)points and VRS was(1.2±0.2)points,which were significantly lower than the control group’s PBAC(54.9±5.9)points and VRS(1.9±0.1)points,the difference was statistically significant(P<0.05);the total effective rate of treatment in the observation group was 94.9%,which was higher than the control group’s 61.5%,and the difference was statistically significant(χ^(2)=12.712,P<0.05);the incidence of adverse reactions in the observation group was 7.7%,which was significantly lower than 28.2%in the control group,and the difference was statistically significant(χ^(2)=5.571,P<0.05).Conclusion The application of leuprolide combined with Mirena in patients with adenomyosis can achieve ideal results.It can significantly improve the menstrual condition of patients and reduce the occurrence of adverse reactions.It is worthy of vigorous promotion and application.
作者
刘红
夏敬梅
李相相
LIU Hong;XIA Jingmei;LI Xiangxiang(Department of Obstetrics and Gynecology,Hongze District People's Hospital,Huai'an,Jiangsu Province,223100 China;Department of Gynecology,Hongze District Hospital of Traditional Chinese Medicine,Huai'an,Jiangsu Province,223100 China)
出处
《系统医学》
2021年第9期118-120,共3页
Systems Medicine
