摘要
目的观察枳壳煮散联合阿托伐他汀治疗冠心病(CHD)肝郁气滞型的疗效及对患者sICAM、NLRP3活性水平的影响。方法选择134例冠心病患者,随机分为对照组与观察组,各67例。对照组给予包含阿托伐他汀的西医常规疗法治疗,观察组在对照组基础上给予枳壳煮散治疗,连续治疗8周。治疗后评估2组临床疗效,并比较2组治疗前后中医症状积分、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、三酰甘油(TG)和总胆固醇(TC)、NLRP3、白细胞介素1β(IL-1β)、白细胞介素18(IL-18)、C反应蛋白(CRP)、可溶性细胞间黏附分子1(sICAM-1)水平和2组患者不良反应情况。结果观察组治疗后有效率(98.51%,66/67)明显高于对照组(85.07%,57/66)(P<0.05);2组治疗后中医症状积分、NLRP3、IL-1β、IL-18、sICAM-1、CRP、LDL-C、TC、TG均较治疗前显著降低(P<0.05),且观察治疗后上述指标降低更为明显(P<0.05);2组治疗后HDL-C均较治疗前显著升高(P<0.05),且观察组治疗后上述指标升高更为明显(P<0.05);2组均未见明显不良反应。结论枳壳煮散联合阿托伐他汀治疗冠心病可改善炎症反应程度,减轻动脉粥样硬化进展,改善中医症状积分,提高临床有效率,安全性良好。
Objective To observe the curative effect of Boiled Zhike Powder combined with atorvastatin in the treatment of coronary heart disease(CHD)with liver depression and qi stagnation syndorme and its infl uence on the activity levels of sICAM and NLRP3.Methods A total of 134 patients with coronary heart disease were randomly divided into control group and observation group,67 cases in each group.The control group was treated with the conventional western medicine therapy,including atorvastatin,and the observation group was treated with Boiled Zhike Powder on the basis of the control group for 8 consecutive weeks.After treatment,the clinical effi cacy of the two groups was evaluated,and the TCM symptom score,levels of low density lipoprotein(LDL-C),high density lipoprotein(HDL-C),triglyceride(TG),total cholesterol(TC),NLRP3,interleukin-1(IL-1β),interleukin-18(IL-18),C-reactive protein(CRP),soluble intercellular adhesion molecule-1(sICAM-1)and adverse reaction were compared between the two groups before and after treatment.Results The eff ective rate of the observation group(98.51%,66/67)was signifi cantly higher than that of the control group(85.07%,57/66)(P<0.05).After treatment,the TCM symptom score,NLRP3,IL-1β,IL-18,sICAM-1,CRP,LDL-C,TC and TG in both groups were significantly decreased compared with those before treatment(P<0.05),and the above indexes in the observation group were decreased more signifi cantly(P<0.05).After treatment,HDL-C in both groups was signifi cantly increased than that before treatment(P<0.05),and the observation group was more significantly increased(P<0.05).There were no obvious adverse reactions in both groups.Conclusion Boiled Zhike Powder combined with atorvastatin in the treatment of coronary heart disease can improve the degree of infl ammatory reaction,reduce the progression of atherosclerosis,improve the TCM symptom score,improve the clinical eff ectiveness,and have good safety.
作者
崔晓敬
朱云霞
赵春梅
王君
武剑
张志强
王志军
CUI Xiaojing;ZHU Yunxia;ZHAO Chunmei;WANG Jun;WU Jian;ZHANG Zhiqiang;WANG Zhijun(Department of Cardiology,Langfang Hospital of Traditional Chinese Medicine,Langfang 065000,China;Affi liated Hospital of North China University of Science and Technology,Tangshan 063000,China)
出处
《吉林中医药》
2021年第7期890-894,共5页
Jilin Journal of Chinese Medicine
基金
河北省廊坊市卫生局科研项目(2017013069)。
