摘要
目的:探讨新型冠状病毒肺炎(COVID-19)患者输注康复者恢复期血浆(CP)前后相关实验室指标的变化。方法:11例患者(重型4例,危重型7例)接受COVID-19 CP输注,输注前后进行咽拭子SARS-CoV-2核酸、动脉血血气分析、炎症相关指标、肝肾功能、凝血功能、心肌标志物等实验室指标的检测。结果:重型患者4例从确诊到输注COVID-19 CP的时间为10~25 d,输注后1~2 d咽拭子核酸全部转阴。危重型患者7例从确诊到输注CP的时间为13~24 d,5例输注后2~5 d咽拭子核酸转阴,2例核酸未转阴者分别于输注后第3天和第6天死亡。重型和危重型患者输注后24和(或)48 h,动脉氧分压和氧合指数升高,白细胞计数、C反应蛋白、降钙素原、D-二聚体、N端脑钠肽前体水平降低,淋巴细胞绝对值增高。结论:COVID-19 CP治疗可以使核酸转阴,改善氧合,减轻炎症反应。
Aim:To investigate the cchanges of relevant laboratory indexes of COVID-19 patients before and after convalescent plasma(CP)transfusion.Methods:Eleven patients with COVID-19(4 severe patients and 7 critical patients)were tested for SARS-CoV-2 RNA,blood gas analysis,inflammation related indicators,liver and kidney function test,coagulation test,myocardial markers and other related indicators before and after COVID-19 CP transfusion.Results:The time from diagnosis to transfusion was 10-25 days in 4 severe patients,the nucleic acid of pharyngeal swab turned negative 1-2 days after CP transfusion.The time from diagnosis to transfusion was 13-24 days in 7 critical patients,and the nucleic acid of pharyngeal swab turned negative in 5 patients 2-5 days after transfusion.After COVID-19 CP transfusion,the arterial partial pressure of oxygen and oxygenation index increased,the white blood cell counting,C-reactive protein,procalcitonin,D-dimer,N-terminal pro brain natriuretic peptide decreased,and the absolute value of lymphocytes increased in severe and critical patients.Conclusion:COVID-19 CP can turn SARS-CoV-2 RNA negative,improve the oxygen partial pressure and oxygenation index,and reduce the inflammation.
作者
邵明
杨乾坤
李建斌
朱伟涛
靳慧芳
赵言腾
王静
孔永奎
谢莹
吕先萍
SHAO Ming;YANG Qiankun;LI Jianbin;ZHU Weitao;JIN Huifang;ZHAO Yanteng;WANG Jing;KONG Yongkui;XIE Ying;LYU Xianping(Department of Blood Transfusion,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Henan Red Cross Blood Center,Zhengzhou 450000;Department of Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)
出处
《郑州大学学报（医学版）》
CAS
北大核心
2021年第3期412-417,共6页
Journal of Zhengzhou University(Medical Sciences)
