围绝经期冠心病患者血清性激素水平与心血管不良事件的相关性被引量：8

Correlations between serum levels of sex hormones and adverse cardiovascular events in perimenopausal patients with coronary heart disease

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摘要目的观察围绝经期冠心病患者血清性激素水平与心血管不良事件发生情况,分析围绝经期冠心病患者血清性激素水平与心血管不良事件的相关性。方法选取2019年1月-2020年2月该院收治的82例围绝经期冠心病患者作为研究对象。观察全部患者的心血管不良事件发生情况;依据心血管不良事件发生情况,将82例围绝经期冠心病患者分为发生组(18例)和未发生组(64例),对比两组入院当天的血清性激素水平,并分析血清性激素水平与心血管不良事件之间的相关性。结果82例围绝经期冠心病患者中,有18例患者发生心血管不良事件;发生组雌二醇(E_(2))、孕酮(P)、睾酮(T)、卵泡刺激素(FSH)及黄体生成素(LH)水平低于未发生组,差异有统计学意义(P<0.05);回归分析检验结果显示,E_(2)、P、T、FSH及LH均可能是围绝经期冠心病患者心血管不良事件发生的影响因素(OR>1,P<0.05);绘制受试者工作特征曲线(ROC)得到各检验变量(E_(2)、P、T、FSH及LH),预测围绝经期冠心病患者心血管不良事件发生风险的ROC曲线下面积(AUC)分别为:0.958、0.888、0.872、0.892及0.758,均>0.75,有一定预测价值,且以E_(2)的预测价值最好。结论围绝经期冠心病患者普遍存在血清性激素水平异常改变的情况,这可能是提高患者心血管不良事件发生风险的影响因子,临床应尽早检测围绝经期冠心病患者血清性激素水平,并针对性采取合理干预,以减少心血管不良事件的发生。 Objective To detect the serum levels of sex hormones in perimenopausal patients with coronary heart disease,observe adverse cardiovascular events,and analyze the correlations between serum levels of sex hormones and adverse cardiovascular events.Methods From January 2019 to February 2020,82 perimenopausal patients with coronary heart disease treated in Dagang Hospital of Binhai New Area were selected,adverse cardiovascular events were observed,the patients were divided into adverse cardiovascular event group(18 cases)and non-adverse cardiovascular event group(64 cases),serum levels of sex hormones on the day of admission in the two groups were compared,the correlations between serum levels of sex hormones and adverse cardiovascular events were analyzed.Results Among 82 perimenopausal patients with coronary heart disease,18 patients had adverse cardiovascular events;the levels of estradiol(E_(2)),progesterone(P),testosterone(T),follicle-stimulating hormone(FSH),and luteinizing hormone(LH)in adverse cardiovascular event group were statistically significantly lower than those in non-adverse cardiovascular event group(P<0.05);regression analysis showed that E_(2),P,T,FSH,and LH were influencing factors of adverse cardiovascular events in perimenopausal patients with coronary heart disease(OR>1,P<0.05).ROC curve was drawn to obtain variables(E_(2),P,T,FSH,and LH),the areas under ROC curve in predicting risk of adverse cardiovascular events in perimenopausal patients with coronary heart disease were 0.958,0.888,0.872,0.892,and 0.758,respectively,which were all higher than 0.75,the variables had predictive value,the predictive value of E_(2) was the best.Conclusion Abnormal changes of serum levels of sex hormones are common in perimenopausal patients with coronary heart disease,which may be the influencing factors of adverse cardiovascular events,serum levels of sex hormones should be detected early,corresponding intervention measures should be taken to reduce adverse cardiovascular events.

作者李跃香王贵荣杨书凤金川田家娟 LI Yue-Xiang;WANG Gui-Rong;YANG Shu-Feng(Dagang Hospital of Binhai New Area,Tianjin,300270,China)

机构地区天津市滨海新区大港医院

出处《中国妇幼保健》 CAS 2021年第12期2882-2885,共4页 Maternal and Child Health Care of China

基金天津市滨海新区卫生计生委科技项目(2018BWKY020)。

关键词冠心病围绝经期血清性激素心血管不良事件相关性 Coronary heart disease Perimenopausal period Serum sex hormone Adverse cardiovascular event Correlation

分类号 R541.4 [医药卫生—心血管疾病]