摘要
目的分析特发性震颤(ET)患者发生焦虑或抑郁的独立危险因素。方法收集2017年5月至2020年5月于郑州大学第一附属医院神经内科住院并确诊的86例ET患者的临床资料。根据是否存在焦虑将患者分为焦虑组和非焦虑组。根据是否存在抑郁将患者分为抑郁组和非抑郁组。收集患者的一般情况、合并症以及运动特征等资料。采用多因素logistic回归分析ET患者发生焦虑或抑郁的危险因素。结果非焦虑组54例(62.79%),焦虑组32例(37.21%)。多因素回归分析显示,女性(OR=9.659,P=0.001)、病程(OR=1.103,P=0.014)、伴其他部位震颤(OR=6.196,P=0.021)是ET患者发生焦虑的独立危险因素。非抑郁组68例(79.07%),抑郁组18例(20.93%)。多因素回归分析显示,女性(OR=5.585,P=0.016)、伴其他部位震颤(OR=6.420,P=0.032)、婚姻状况(未婚、离异或丧偶)(OR=5.399,P=0.041)是ET患者发生抑郁的独立危险因素。结论女性和除双上肢外伴有其他部位震颤的ET患者容易发生焦虑或抑郁。病程越长,焦虑风险也越高。未婚、离异或丧偶的ET患者发生抑郁的可能性也增加。
Objective To analyze the independent risk factors of anxiety or depression in patients with essential tremor(ET).Methods The clinical data of 86 patients with ET who were hospitalized and diagnosed in the Department of Neurology of the First Affiliated Hospital of Zhengzhou University from May 2017 to May 2020 were collected.According to whether there was anxiety,the patients were divided into anxiety group and non-anxiety group.According to whether there was depression,the patients were divided into depression group and non-depression group.The patients’general condition,complications,movement characteristics and other data were collected.Multivariate logistic regression was used to analyze the risk factors of anxiety or depression in patients with ET.Results There were 54 cases(62.79%)in non-anxiety group and 32 cases(37.21%)in anxiety group.Multivariate regression analysis showed that female(OR=9.659,P=0.001),the course of disease(OR=1.103,P=0.014)and with other parts of tremor(OR=6.196,P=0.021)were independent risk factors for anxiety in the patients with ET.There were 68 cases(79.07%)in non-depression group and 18 cases(20.93%)in depression group.Multivariate regression analysis showed that female(OR=5.585,P=0.016),with other parts of tremor(OR=6.420,P=0.032)and marital status(unmarried,divorced or widowed)(OR=5.399,P=0.041)were independent risk factors for depression in the patients with ET.Conclusion Female and ET patients with tremors in other parts except upper limbs are prone to anxiety or depression.The longer the course of disease,the higher the risk of anxiety.Unmarried,divorced or widowed ET patients are also more likely to suffer from depression.
作者
张新凯
朱红灿
王源培
高萌
ZHANG Xinkai;ZHU Hongcan;WANG Yuanpei;GAO Meng(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《河南医学研究》
CAS
2021年第16期2901-2905,共5页
Henan Medical Research
关键词
特发性震颤
焦虑
抑郁
危险因素
essential tremor
anxiety
depression
risk factor
