摘要
目的:观察加味升降散治疗青壮年高脂血症患者的临床疗效。方法:将96例青壮年高脂血症患者,随机分为观察组与对照组,每组各48例。两组均予以常规治疗,观察组予以加味升降散颗粒,对照组加服安慰剂。两组疗程均为3个月,观察两组治疗有效率,比较血脂、同型半胱氨酸和颈动脉内膜中层厚度的情况。结果:(1)最终完成试验者78例,观察组38例,对照组40例。(2)观察组有效30例,无效8例,有效率为78.9%,而对照组有效19例,无效21例,有效率为47.5%;组间有效率比较差异有统计学意义(P<0.05)。(3)组间治疗后比较,观察组TC、TG、LDL-C和Apo B100水平明显降低,HDL-C、Apo AI水平明显升高,与对照组相比改善明显,差异有统计学意义(P<0.05)。(4)组间治疗后比较,观察组Hcy、IMT的水平均明显降低,与对照组相比差异有统计学意义(P<0.05)。结论:加味升降散治疗青壮年高脂血症患者的临床疗效满意,可明显改善患者脂质代谢,有效降低患者血清Hcy水平,改善IMT厚度,值得临床上进一步推广应用。
OBJECTIVE To investigate the clinical effect of Jiawei Shengjiang Powder on the treatment of young adults patients with hyperlipidemia. METHODS Ninety-six patients with hyperlipidemia were randomly divided into treatment group and control groupwith 48 cases in each group. Both groups were treated with conventional therapy. The treatment group was treated with Jiawei Shengjiang decoction,and the control group was given with placebo. The course of treatment was 3 months. The two groups were observed to compare the blood lipid,blood glucose,uric acid,C-reactive protein,homocysteine,apolipoprotein and carotid intimamedia thickness. RESULTS The final test was performed in 78 patients,38 in the treatment group and 40 in the control group.The treatment group was effective in 30 cases,ineffective in 8 cases,the effective rate was 78.9%,while the control group was effective in 19 cases and ineffective in 21 cases,the effective rate was 47.5%;the difference in the effective rate between the groups was statistically significant,and the treatment group was significantly higher than control group. After treatment,the levels of TC,TG,LDL-C and ApoB100 in the treatment group were significantly decreased,while the levels of HDL-C and Apo AI in the treatment group were significantly increased. Compared with the control group,the differences were statistically significant. After treatment,the Hcy and IMT levels in the treatment group were significantly reduced,and the difference was statistically significant compared with the control group. CONCLUSION Jiawei Shengjiang Powder had a satisfactory clinical effect in the treatment of young adults with hyperlipidemia,which could significantly improve lipid metabolism,effectively reduce the serumHcy level of the patients,and improve the thickness of IMT,and is worthy of further clinical application.
作者
麦静愔
何青青
温洁
MAI Jing-yin;HE Qing-qing;Wen Jie(Shanghai Pudong New District Hospital of Traditional Chinese Medicine,Shanghai,201220,China;不详)
出处
《中国初级卫生保健》
2021年第5期68-70,共3页
Chinese Primary Health Care
基金
上海市浦东新区科技发展基金项目(PKJ2016-Y21)。
